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Pharmaceutics
Special Issues
Applications of Polymer Blends in Drug Technology
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Applications of Polymer Blends in Drug Technology

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 854

Special Issue Editor

Dr. Pompilia Ispas-Szabo

E-Mail Website
Guest Editor
Département de Chimie, Université du Québec à Montréal, Montréal, QC, Canada
Interests: biopolymers; pharmaceutical excipients; polymers

Special Issue Information

Dear Colleagues,

Polymers used in drug delivery are essential in product formulation and technology. As excipients, they face numerous limitations required by safety protocols for approval; thus, there has been great interest in the characteristics of blending already-approved polymers, which could provide viable solutions in the field of drug delivery. The applications of polymer blends include usage as general excipients in delivery systems, coatings, oral films, biodegradable systems, and so on, with these valuable resources having significant advantages. In addition to existent drugs, for newly approved substances and drug development, polymer blends can overcome drug delivery challenges and/or help expand applications in pharmaceutical products. This Special Issue welcomes all new research on polymers and polymer blends, with particular focus on pharmaceutical formulations.

Dr. Pompilia Ispas-Szabo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymers
  • polymer blends
  • drug formulation
  • drug delivery
  • excipients

Published Papers (1 paper)

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Research

22 pages, 5286 KiB  
Article
Novel Organogels from Mauritia flexuosa L.f and Caryodendron orinocense Karst.: A Topical Alternative
by Luis Eduardo Mosquera Narvaez, Marcela P. Carrillo, Juliana E. C. Cardona-Jaramillo, Bibiana Margarita Vallejo, Lindalva Maria de Meneses Costa Ferreira, José Otávio Carréra Silva-Júnior and Roseane Maria Ribeiro-Costa
Pharmaceutics 2023, 15(12), 2681; https://doi.org/10.3390/pharmaceutics15122681 - 27 Nov 2023
Viewed by 683
Abstract
Organogels have importance for topical applications because they can be used to deliver drugs in a controlled and prolonged fashion. These are materials consisting of a three-dimensional network of organic molecules dispersed in a solvent. Recent studies have demonstrated that the solvent could [...] Read more.
Organogels have importance for topical applications because they can be used to deliver drugs in a controlled and prolonged fashion. These are materials consisting of a three-dimensional network of organic molecules dispersed in a solvent. Recent studies have demonstrated that the solvent could be replaced by oils from non-conventional biologic sources. There is a diversity of not-explored species in the Amazon that are promising sources of vegetable oils with a promising composition. This study developed an organogel with buriti (Mauritia flexuosa L.f) and cacay (Caryodendron orinocense Karst.) oils, using cetostearyl alcohol as an organogelator due to its compatibility, stability, security, affordability, and it is readily available. The oils were characterized, and the organogels were synthesized by studying their crystal evolution and oil-binding capacity. The microstructure was evaluated with polarized light microscopy, fractal dimension, FTIR spectroscopy, XRD, and thermal and rheological analyses. It was found that the critical gelation concentration was higher for cacay oil as it possessed a higher amount of polyunsaturated triacylglycerols. The crystals of the buriti organogel had a smaller lamellar shape, a greater surface area, and physical and thermal stability; although, it presented a slower crystal evolution due to the low number of minor compounds and a greater number of saturated triacylglycerols. The polar fraction of the organogelators as well as triacylglycerol and minor polar compounds are important in forming crystallization nuclei. The study showed that Amazonian oils in crystallization processes form microstructures with differentiating physicochemical properties. Full article
(This article belongs to the Special Issue Applications of Polymer Blends in Drug Technology)
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