Nanomaterials Application as Drug Delivery Systems to the Treatment of Neurodegenerative Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (25 November 2023) | Viewed by 1120

Special Issue Editors


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Guest Editor
Instituto Nacional de Neurología y Neurocirugía, Tlalpan, Mexico
Interests: nanomaterials synthesis; inorganic nanomaterials; organic nanomaterials; nanomaterials characterization; drug delivery; neurodegenerative diseases; brain tumors

E-Mail Website
Guest Editor
Instituto Nacional de Neurología y Neurocirugía, Tlalpan, Mexico
Interests: neurodegeneration; Alzheimer disease; epilepsy; Parkinson; tau protein; amyloid b

E-Mail Website
Guest Editor
Instituto Nacional de Neurología y Neurocirugía, Tlalpan, Mexico
Interests: neurodegenerative diseases; brain tumors; cancer biology; cell signaling; biocompatibility; drug delivery; nanotechnology

Special Issue Information

Dear Colleagues,

Nowadays, the survival time of people has increased considerably, but unfortunately, their quality of life is not desirable. The long survival time allows us to observe the development of degenerative diseases such as neurodegenerative diseases. These later are characterized by the progressive loss of the structure or function of neurons, which often leads to neuronal death, affecting functions related to movement, memory, and dementia, among others. Its treatment is complicated because the drugs cause severe side effects since many cross the blood-brain barrier in small quantities, leading to increased doses to reach the adequate therapeutic amount. Therefore, using inorganic and organic nanomaterials and their combination as controlled drug delivery systems is an alternative because most are biocompatible with the human body. In addition, they can be functionalized to be directed to specific targets and cross the blood-brain barrier. Therefore, it is interesting to know the current nanomaterials' state of the art in applying neurological drug delivery systems to treat various neurodegenerative diseases.

Dr. Emma Ortiz-Islas
Dr. Victoria Campos-Peña
Dr. Citlali Ekaterina Rodríguez Pérez
Guest Editors

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Keywords

  • nanomaterials
  • drug delivery
  • neurodegenerative diseases
  • blood-brain barrier
  • functionalization
  • neuronal death
  • biocompatible

Published Papers (1 paper)

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Research

22 pages, 4882 KiB  
Article
The Impact of Serum Protein Adsorption on PEGylated NT3–BDNF Nanoparticles—Distribution, Protein Release, and Cytotoxicity in a Human Retinal Pigmented Epithelial Cell Model
by Maria Dąbkowska, Alicja Kosiorowska and Bogusław Machaliński
Pharmaceutics 2023, 15(9), 2236; https://doi.org/10.3390/pharmaceutics15092236 - 30 Aug 2023
Cited by 3 | Viewed by 808
Abstract
The adsorption of biomolecules on nanoparticles’ surface ultimately depends on the intermolecular forces, which dictate the mutual interaction transforming their physical, chemical, and biological characteristics. Therefore, a better understanding of the adsorption of serum proteins and their impact on nanoparticle physicochemical properties is [...] Read more.
The adsorption of biomolecules on nanoparticles’ surface ultimately depends on the intermolecular forces, which dictate the mutual interaction transforming their physical, chemical, and biological characteristics. Therefore, a better understanding of the adsorption of serum proteins and their impact on nanoparticle physicochemical properties is of utmost importance for developing nanoparticle-based therapies. We investigated the interactions between potentially therapeutic proteins, neurotrophin 3 (NT3), brain-derived neurotrophic factor (BDNF), and polyethylene glycol (PEG), in a cell-free system and a retinal pigmented epithelium cell line (ARPE-19). The variance in the physicochemical properties of PEGylated NT3–BDNF nanoparticles (NPs) in serum-abundant and serum-free systems was studied using transmission electron microscopy, atomic force microscopy, multi-angle dynamic, and electrophoretic light scattering. Next, we compared the cellular response of ARPE-19 cells after exposure to PEGylated NT3–BDNF NPs in either a serum-free or complex serum environment by investigating protein release and cell cytotoxicity using ultracentrifuge, fluorescence spectroscopy, and confocal microscopy. After serum exposure, the decrease in the aggregation of PEGylated NT3–BDNF NPs was accompanied by increased cell viability and BDNF/NT3 in vitro release. In contrast, in a serum-free environment, the appearance of positively charged NPs with hydrodynamic diameters up to 900 nm correlated with higher cytotoxicity and limited BDNF/NT3 release into the cell culture media. This work provides new insights into the role of protein corona when considering the PEGylated nano–bio interface with implications for cytotoxicity, NPs’ distribution, and BDNF and NT3 release profiles in the in vitro setting. Full article
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