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Pharmaceutics
Special Issues
Research and Development of Novel MOFs (Metal-Organic Framework) Drug Formulations
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Special Issue "Research and Development of Novel MOFs (Metal-Organic Framework) Drug Formulations"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3801

Special Issue Editor

Dr. Jian-Qiang Liu

E-Mail Website
Guest Editor
Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China
Interests: drug delivery; MOF; chemotherapeutics agents; MRI; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal–organic frameworks (MOFs) are typical coordination polymers constructed by metal ions/clusters and multitopic organic ligands. Compared with traditional porous materials, MOFs have the advantages of significant porosity, large specific surface area, adjustable chemical composition, and structure tailorability; these unique features make them a promising candidate for controlled drug delivery. This Special Issue aims to collect the recent advances in the development of MOFs for drug delivery, in particular focusing on their ability to deliver various drugs and their release mechanisms, as well as the in vivo and in vitro biological evaluation.

Jianqiang Liu obtained his PhD degree from Northwest University, China, in 2010. After he joined the School of Pharmacy at the Guangdong Medical University as an Assistant Professor in 2012. He was promoted to a Full Professor in 2018. From 2012 to 2019, he worked as a senior visiting scholar at Tsinghua University, Sun Yat-sen Medical University in Taiwan and Yamagata University in Japan. His current research interest focuses on the development of functional materials including metal–organic frameworks (MOFs) and porous organic polymers (POPs) for energy, biology, and environment-related applications.

Dr. Jian-Qiang Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MOF
  • drug delivery
  • tumor therapy
  • cell membrane
  • MRI
  • CDT
  • PDT
  • PTT
  • nano-enzymes
  • sensing
  • oxygen species (ROS)
  • antibacterial therapy

Published Papers (3 papers)

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Review
A Novel Platform of MOF for Sonodynamic Therapy Advanced Therapies
by
Donghui Liao
,
Jiefeng Huang
,
Chenyi Jiang
,
Luyi Zhou
,
Mingbin Zheng
,
Alireza Nezamzadeh-Ejhieh
,
Na Qi
,
Chengyu Lu
and
Jianqiang Liu
Pharmaceutics 2023, 15(8), 2071; https://doi.org/10.3390/pharmaceutics15082071 - 01 Aug 2023
Viewed by 615
Abstract
Metal–organic frameworks (MOFs) combined with sonodynamic therapy (SDT) have been introduced as a new and efficient treatment method. The critical advantage of SDT is its ability to penetrate deep tissues and concentrate energy on the tumor site to achieve a non-invasive or minimally [...] Read more.
Metal–organic frameworks (MOFs) combined with sonodynamic therapy (SDT) have been introduced as a new and efficient treatment method. The critical advantage of SDT is its ability to penetrate deep tissues and concentrate energy on the tumor site to achieve a non-invasive or minimally invasive effect. Using a sonosensitizer to generate reactive oxygen species (ROS) under ultrasound is the primary SDT-related method of killing tumor cells. In the presence of a sonosensitizer, SDT exhibits a more lethal effect on tumors. The fast development of micro/nanotechnology has effectively improved the efficiency of SDT, and MOFs have been broadly evaluated in SDT due to their easy synthesis, easy surface functionalization, high porosity, and high biocompatibility. This article reviews the main mechanism of action of sonodynamic therapy in cancer treatment, and also reviews the applications of MOFs in recent years. The application of MOFs in sonodynamic therapy can effectively improve the targeting ability of SDT and the conversion ability of reactive oxygen species, thus improving their killing ability on cancer cells. This provides new ideas for the application of micro/nano particles in SDT and cancer therapy. Full article
(This article belongs to the Special Issue Research and Development of Novel MOFs (Metal-Organic Framework) Drug Formulations)
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Review
Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications
by
Weipeng Chen
,
Miao Liu
,
Hanping Yang
,
Alireza Nezamzadeh-Ejhieh
,
Chengyu Lu
,
Ying Pan
,
Jianqiang Liu
and
Zhi Bai
Pharmaceutics 2023, 15(5), 1323; https://doi.org/10.3390/pharmaceutics15051323 - 23 Apr 2023
Cited by 11 | Viewed by 1378
Abstract
Metal–phenolic networks (MPNs) are a new type of nanomaterial self-assembled by metal ions and polyphenols that have been developed rapidly in recent decades. They have been widely investigated, in the biomedical field, for their environmental friendliness, high quality, good bio-adhesiveness, and bio-compatibility, playing [...] Read more.
Metal–phenolic networks (MPNs) are a new type of nanomaterial self-assembled by metal ions and polyphenols that have been developed rapidly in recent decades. They have been widely investigated, in the biomedical field, for their environmental friendliness, high quality, good bio-adhesiveness, and bio-compatibility, playing a crucial role in tumor treatment. As the most common subclass of the MPNs family, Fe-based MPNs are most frequently used in chemodynamic therapy (CDT) and phototherapy (PTT), where they are often used as nanocoatings to encapsulate drugs, as well as good Fenton reagents and photosensitizers to improve tumor therapeutic efficiency substantially. In this review, strategies for preparing various types of Fe-based MPNs are first summarized. We highlight the advantages of Fe-based MPNs under the different species of polyphenol ligands for their application in tumor treatments. Finally, some current problems and challenges of Fe-based MPNs, along with a future perspective on biomedical applications, are discussed. Full article
(This article belongs to the Special Issue Research and Development of Novel MOFs (Metal-Organic Framework) Drug Formulations)
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Review
Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release
by
Ziao Zong
,
Guanghui Tian
,
Junli Wang
,
Chuanbin Fan
,
Fenglian Yang
and
Feng Guo
Pharmaceutics 2022, 14(12), 2790; https://doi.org/10.3390/pharmaceutics14122790 - 13 Dec 2022
Cited by 3 | Viewed by 1446
Abstract
Metal–organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery [...] Read more.
Metal–organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery and release because of their good biocompatibility and high-drug-loading capacity. Herein, we provide a comprehensive summary of MOF-based nanocarriers for drug delivery and release over the last five years. Meanwhile, some representative examples are highlighted in detail according to four categories, including the University of Oslo MOFs, Fe-MOFs, cyclodextrin MOFs, and other MOFs. Moreover, the opportunities and challenges of MOF-based smart delivery vehicles are discussed. We hope that this review will be helpful for researchers to understand the recent developments and challenges of MOF-based drug-delivery systems. Full article
(This article belongs to the Special Issue Research and Development of Novel MOFs (Metal-Organic Framework) Drug Formulations)
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