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Pharmaceutics
Special Issues
Essential Oils in Pharmaceutical Products (Volume II)
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Special Issue "Essential Oils in Pharmaceutical Products (Volume II)"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 3562

Special Issue Editors

Dr. Aurica P. Chiriac

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Guest Editor
“Petru Poni” Macromolecular Chemistry Institute, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania
Interests: polymers synthesis, including by nonconventional methods; chemical modifications; hydrogels; polymeric matrices for bioapplications; nanoparticles; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Alina Gabriela Rusu

E-Mail Website
Guest Editor
"Petru Poni" Institute of Macromolecular Chemistry, Iasi, Romania
Interests: hydrogels; modified polysaccharides; nanogels; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The importance of using essential oils (EOs) in various fields not only derives from the need to sustain bio-based compounds and decrease the dependence on and replace synthetic products with others of natural origin; it is especially due to the fact that these products have been tested and their effect and efficacy have been confirmed in medicine, pharmaceutical sciences, biology, agronomy, etc., with evidence from the oldest times. At present, the growing interest in the use of these compounds is a result of the new and multiple possibilities to protect these structures from external factors (e.g., light, oxygen, temperature) offered by both the innovative matrices created but also by the new incorporation techniques that can further ensure the manifestation of EOs’ biochemical and pharmacological activities. Finally, we must mention the increased capacity to characterize the products that include EOs, and to evaluate the activity and nature of their properties resulting from the presence of EOs in their composition. In this context, the aim of this Special Issue on “Essential Oils in Formulations for Specific Therapies and Products” is to gather papers addressing state-of-the-art trends, future directions, and challenges in the development of formulations based on essential oils, their carriers, and their applicability and uses in various fields due to the chemical composition of the essential oils and correlated effects. Original research papers, communications, review articles, and opinions are welcome.

Dr. Aurica P. Chiriac
Dr. Alina Gabriela Rusu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • EOs as active chemicals
  • EOs' biological activity (antimicrobial, insecticidal, herbicidal, bactericidal, and fungicidal properties)
  • EOs encapsulation procedures
  • EOs for improving human health
  • EOs in active packaging products
  • polymeric networks for EOs encapsulation

Related Special Issue

Published Papers (3 papers)

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Article
Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology
by
Jae Yoon Chung
,
Nayoung Park
,
Mi Hye Kim
and
Woong Mo Yang
Pharmaceutics 2023, 15(4), 1195; https://doi.org/10.3390/pharmaceutics15041195 - 09 Apr 2023
Viewed by 955
Abstract
Abies holophylla is an evergreen coniferous species that has been widely used for treating pulmonary diseases and colds. Previous research has demonstrated the anti-inflammatory effect of Abies species and the anti-asthmatic activities of Abies holophylla leaf essential oil (AEO). As asthma and allergic [...] Read more.
Abies holophylla is an evergreen coniferous species that has been widely used for treating pulmonary diseases and colds. Previous research has demonstrated the anti-inflammatory effect of Abies species and the anti-asthmatic activities of Abies holophylla leaf essential oil (AEO). As asthma and allergic rhinitis (AR) share pathophysiology and pharmacotherapeutic interventions, AEO inhalation can also ameliorate upper respiratory allergic diseases. This study explored the protective effects of AEO on AR with network pharmacological pathway prediction. The potential target pathways of AEO were analyzed by a network pharmacological approach. The BALB/c mice were sensitized by ovalbumin (OVA) and 10 μm particular matter (PM10) to induce allergic rhinitis. Aerosolized AEO 0.0003% and 0.03% were delivered by nebulizer for 5 min a day, 3 times a week for 7 weeks. Nasal symptoms (sneezing and rubbing), histopathological changes in nasal tissues, serum IgE, and zonula occludens-1 (ZO-1) expressions on nasal tissues were analyzed. After AR induction with OVA+PM10 and inhalation of AEO 0.0003% and 0.03% treatment, AEO significantly decreased allergic symptoms (sneezing and rubbing), hyperplasia of nasal epithelial thickness, goblet cell counts, and serum IgE level. The network analysis demonstrated that the possible molecular mechanism of AEO is highly associated with the IL-17 signaling pathway and tight junction. The target pathway of AEO was investigated in RPMI 2650 nasal epithelial cells. Treatment of AEO on PM10-treated nasal epithelial cells significantly reduced the production of inflammatory mediators related to the IL-17 signaling pathway, NF-κB, and the MAPK signaling pathway and prevented the reduction in TJ-related factors. When taken together, AEO inhalation may be considered as a potential treatment for AR by alleviating nasal inflammation and recovering the tight junction. Full article
(This article belongs to the Special Issue Essential Oils in Pharmaceutical Products (Volume II))
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Article
Nutmeg Essential Oil, Red Clover, and Liquorice Extracts Microencapsulation Method Selection for the Release of Active Compounds from Gel Tablets of Different Bases
by
Jurga Andreja Kazlauskaite
,
Inga Matulyte
,
Mindaugas Marksa
and
Jurga Bernatoniene
Pharmaceutics 2023, 15(3), 949; https://doi.org/10.3390/pharmaceutics15030949 - 15 Mar 2023
Cited by 2 | Viewed by 1018
Abstract
The current study presents the most suitable method for encapsulating nutmeg essential oil with liquorice and red clover. Two widely used methods, spray-drying and freeze-drying, were employed to find the most suitable for essential oil volatile compounds’ protection. Results showed that freeze-dried capsules [...] Read more.
The current study presents the most suitable method for encapsulating nutmeg essential oil with liquorice and red clover. Two widely used methods, spray-drying and freeze-drying, were employed to find the most suitable for essential oil volatile compounds’ protection. Results showed that freeze-dried capsules (LM) had a higher yield (85.34%) compared to the exact formulation of spray-dried microcapsules (SDM)—45.12%. All the antioxidant and total phenolic compounds’ results obtained with the LM sample were significantly higher compared with SDM. LM microcapsules were incorporated in two different bases with no additional sugar (gelatin and pectin) for targeted release. Pectin tablets had firmer and harder texture properties, while gelatin tablets had a more elastic texture. There was a significant impact on texture changes caused by microcapsules. Microencapsulated essential oil with extracts can be used alone or in a gel base (pectin or gelatin, depending on user preferences). It could be an effective product to protect the active volatile compounds and regulate the release of active compounds and give a pleasant taste. Full article
(This article belongs to the Special Issue Essential Oils in Pharmaceutical Products (Volume II))
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Article
Application of Antiviral, Antioxidant and Antibacterial Glycyrrhiza glabra L., Trifolium pratense L. Extracts and Myristica fragrans Houtt. Essential Oil in Microcapsules
by
Jurga Andreja Kazlauskaite
,
Inga Matulyte
,
Mindaugas Marksa
,
Raimundas Lelesius
,
Alvydas Pavilonis
and
Jurga Bernatoniene
Pharmaceutics 2023, 15(2), 464; https://doi.org/10.3390/pharmaceutics15020464 - 30 Jan 2023
Cited by 1 | Viewed by 1205
Abstract
Viruses and bacteria can disrupt normal human functions; therefore, ways to use the beneficial properties of plants to promote health are constantly being researched. Plant materials that accumulate biologically active compounds can be used to create a new pharmaceutical form. This study aimed [...] Read more.
Viruses and bacteria can disrupt normal human functions; therefore, ways to use the beneficial properties of plants to promote health are constantly being researched. Plant materials that accumulate biologically active compounds can be used to create a new pharmaceutical form. This study aimed to investigate the biological activity of selected plant extracts and essential oil and to produce microcapsules. The main compounds in extracts and essential oil were determined using chromatographic methods, antioxidant activity was evaluated spectrophotometrically, antimicrobial activity was assessed by monitoring the growth of nine pathogens, and the antiviral effect on infected bird cells with coronavirus was evaluated. Trifolium pratense L. extract had the highest antioxidant (26.27 ± 0.31 and 638.55 ± 9.14 µg TE/g dw by the DPPH and ABTS methods, respectively) and antiviral activity (56 times decreased titre of virus). Liquorice extract expressed antibacterial activity against Gram-positive pathogens and the highest antioxidant activity using the FRAP method (675.71 ± 4.61 mg FS/g dw). Emulsion stability depended on excipients and their amount. Microcapsules with extracts and essential oil were 1.87 mm in diameter, and their diameter after swelling was increased more than two times in intestinal media, while less than 0.5 times in gastric media. Full article
(This article belongs to the Special Issue Essential Oils in Pharmaceutical Products (Volume II))
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