Special Issue "Host-Direct Immunotherapy and Antivirulence Therapy to Combat Microbial Infections"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 31 July 2023 | Viewed by 93

Special Issue Editors

Biologia Microbiana, Universidade Ceuma (UNICEUMA), Sao Luis, Brazil
Interests: antimicrobial agents; antivirulence agents; immunomodulators; polymers; lectins; polysaccharides; infection models; wound healing; action mechanisms
Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark
Interests: bacterial pathogenesis and host response to the infections; testing drugs and assessing the pathogenicity; bacterial community interactions; microbiota analyses and co-infections; serology

Special Issue Information

Dear Colleagues,

Despite therapeutic advances, microbial infections continue among the leading causes of mortality and morbidity worldwide. The antimicrobial resistance phenomenon has become a global threat to public-health systems, declining the arsenal of drugs available to treat infections. This scenario encourages the exploration of new paradigms to develop new approaches to treat microbial infection, such as those based on the modulation of the host immune system and virulence inhibition.

Host-directed immunotherapy consists of an improvement in host defenses rather than targetting microbe viability or virulence. It acts by enhancing the production of antimicrobial mediators through immune cells and/or regulating the exacerbated inflammation induced by microorganisms, which may promote tissue injury and organ failure.

On the other hand, antivirulence compounds should impair the mechanisms involved in microbial adhesion, colonization, invasion, immune evasion and/or host damage. These compounds should not target microbial growth, inducing lower selective evolutionary pressure on microbial cells than conventional antibiotics.

Thus, this Special Issue aims to highlight the current research on immunomodulatory and antivirulence compounds for the treatment of different types of microbial infections. Manuscripts using in vivo models, including invertebrate organisms, are encouraged. Clinical trials are also welcome.

Prof. Dr. Luís Cláudio Nascimento da Silva
Prof. Dr. Karen Angeliki Krogfelt 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • inflammation
  • virulence factors
  • natural products
  • synthetic compounds
  • cytokines

Published Papers

This special issue is now open for submission.
Back to TopTop