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6.9
5.4
Journals
Pharmaceutics
Special Issues
Drug Interactions of Antimicrobial Agents
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Drug Interactions of Antimicrobial Agents

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (31 May 2011) | Viewed by 24239

Special Issue Editor

Prof. Dr. Federico Pea

E-Mail Website
Guest Editor
1. Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy
2. Director of SSD Clinical Pharmacology, University Hospital IRCCS Policlinico Sant'Orsola, 40126 Bologna, Italy
Interests: clinical pharmacokinetics and pharmacodynamics of antimicrobials; application of therapeutic drug monitoring to optimize and personalize therapy in special patient populations
Special Issues, Collections and Topics in MDPI journals

Keywords

  • cytochrome P450
  • P-glycoprotein
  • inhibition
  • induction
  • antimicrobial agents

Published Papers (2 papers)

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Review

531 KiB  
Review
Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams
by Mathieu S. Bolhuis, Prashant N. Panday, Arianna D. Pranger, Jos G. W. Kosterink and Jan-Willem C. Alffenaar
Pharmaceutics 2011, 3(4), 865-913; https://doi.org/10.3390/pharmaceutics3040865 - 18 Nov 2011
Cited by 39 | Viewed by 14073
Abstract
Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on [...] Read more.
Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs. Full article
(This article belongs to the Special Issue Drug Interactions of Antimicrobial Agents)
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302 KiB  
Review
Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management
by R. Chris Rathbun and Michelle D. Liedtke
Pharmaceutics 2011, 3(4), 745-781; https://doi.org/10.3390/pharmaceutics3040745 - 21 Oct 2011
Cited by 38 | Viewed by 9415
Abstract
Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through cytochrome P450 (CYP450) and uridine diphosphate glucuronosyltransferase (UGT) enzymes and transport by [...] Read more.
Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through cytochrome P450 (CYP450) and uridine diphosphate glucuronosyltransferase (UGT) enzymes and transport by membrane proteins (e.g., p-glycoprotein, organic anion-transporting polypeptide). The clinical significance of antiretroviral drug interactions is reviewed, with a focus on new and investigational agents. An overview of the mechanistic basis for drug interactions and the effect of individual antiretrovirals on CYP450 and UGT isoforms are provided. Interactions between antiretrovirals and medications for other co-morbidities are summarized. The role of therapeutic drug monitoring in the detection and management of antiretroviral drug interactions is also briefly discussed. Full article
(This article belongs to the Special Issue Drug Interactions of Antimicrobial Agents)
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