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Special Issue "Targeted Therapies in Diabetes and Its Complications"
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 16178
Special Issue Editor
Interests: personalized medicine; molecular (pharmaco)epidemiology; diabetes; omics biomarkers; novel therapies
Special Issue Information
Though a substantial proportion of chronic conditions related to diabetes mellitus are associated with aging, glycemic control still plays an important role in the pathogenesis of conditions, such as macro and microvascular diseases. The current treatment algorithm for diabetes is stepwise; drugs are trialed down the long list until an effective medication is reached to control diabetes and its complications. New therapeutic targets, as well as new drug delivery forms in diabetes mellitus treatment, have arisen in recent years. Delivery systems have been found to be potentially beneficial in many aspects for effective diabetes treatment, such as improving the stability of drugs, overcoming different biological barriersin vivoto increase bioavailability, and acting as an intelligent automatized system to mimic endogenous insulin delivery and reduce the risk of hypoglycemia. Guidelines recommend that pharmacological therapy in diabetes should maintain an optimal fasting serum glucose concentration. Yet, favorable responses to such therapeutics are unstable, in which roughly 40% of diabetes patients do not reach the desired glucose level. Several factors may contribute to inter-individual differences in response to medications, including genetic and non-genetic factors. Different factors/biomarkers could potentially predict different responses to glucose-lowering medications.
This Special Issue will cover a wide range of targeting delivery strategies for diabetes treatments. It aims to provide an overview related with the research advances, development trend of drug therapy and the application of delivery systems in the treatment diabetes mellitus, which could offer reference for the application of various drugs in the field of diabetes mellitus treatment. The aim would be to collect studies investigating:
- drug delivery and controlled-release systems for diabetes treatments
- pharmaceutical formulation design for diabetes treatments
- innovative methods to study pathways in response to glucose-lowering medications
- efficacy/effectiveness or safety of different glucose-lowering medications in the context of observational studies or clinical trials
- comparing biomarker-guided diabetes therapy and conventional therapy
- new therapy targets for diabetes and its complications to enable earlier and more effective therapy and prevention
- different factors related to response to glucose-lowering medications in populations with diabetes, for better understanding of pharmacokinetics and pharmacodynamics in drug development of diabetes, through association or prediction studies.
Dr. Fariba Ahmadizar
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- diabetes mellitus
- drug delivery system
- pharmaceutical formulation design
- vulnerable diabetic people
- novel therapies biomarker-guided therapy
- response to medications
- genomics factors
- molecular pathways
- innovative methods
Related Special Issue
- Diabetic Foot in Applied Sciences (23 articles)