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Special Issue "State of the Art of Membrane Active Peptides"
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: 30 November 2023 | Viewed by 9589
Special Issue Editors
Interests: cell penetrating peptides; antimicrobial peptides; fluorescence microscopy; molecular interactions; biomimetic systems; drug delivery systems
2. Department of Chemistry & Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY 13699, USA
3. Center for Fundamental Research and Experimental Development in Translation Medicine–TRANSCEND, Regional Institute of Oncology, 700483 Iasi, Romania
Interests: peptide chemistry; amyloid peptides; mass spectrometry; proteomics; enzymatic substrates; lysosomal rare diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
We are pleased to invite you to contribute to the Special Issue “State-of-the-Art of Membrane-Active Peptides”. This issue is focused on membrane-active peptides that interact with the cell membrane and exert their biological activity by delivering different molecules inside cells or by disrupting the membrane followed cell lysis. Cell-penetrating peptides (CPPs) surmount the membrane barrier and deliver a great number of cargoes into the cells. CPPs act by the direct translocation of the membrane, pore formation or by endocytic routes. Antimicrobial peptides (AMPs) are components of the innate immunity and serve as first line protection against pathogens. Nowadays, multidrug-resistant bacteria to available antibiotics represent a major challenge, and AMPs are used to create a new generation of antibacterial drugs. Antimicrobial peptides target the bacterial membrane and lyse it using different mechanisms, such as the toroidal pore, the carpet model or the barrel stave model. Membrane-active peptides are considered as promising alternatives to current pharmaceuticals. However, their therapeutic potential is restricted by the current understanding of their molecular mechanism of action.
This Special Issue aims to bring together the latest advances regarding the molecular mechanism of peptide internalization, techniques to reveal these modes of peptide uptake and develop new peptide sequences, biological activity, applications and clinical data.
In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, the following:
- Molecular mechanisms of membrane-active peptides;
- Techniques to reveal the molecular mechanisms of membrane-active peptides;
- Recent advances in applications of membrane-active peptides in biotechnology and medicine;
- New peptide sequences and their biological activity;
- Drug delivery systems based on membrane-active peptides.
We look forward to receiving your contributions.
Dr. Corina Ciobanasu
Dr. Brînduşa Alina Petre
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell-penetrating peptides
- antimicrobial peptides
- homing peptides
- drug delivery system
- cellular internalization
- cellular targeting