Delivery Systems on the Antioxidant Activity of Natural Bioactive Compounds

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1588

Special Issue Editors

Institutul National de Cercetare - Dezvoltare pentru Stiinte Biologice, Bucuresti, Bucharest, Romania
Interests: natural extracts; bioavailability; delivery system for antioxidants; oxidative stress

Special Issue Information

Dear Colleagues,

Natural compounds are a source of antioxidants for all living organisms. The mechanisms by which they act at the cellular level are fairly renowned, but in order to manifest their activity, to contribute to the reduction in oxidative stress, and to implicitly reduce the chances of developing chronic diseases, they must reach the cellular level. The main sources of antioxidants are food (fruits, vegetables, teas, coffee, and mushrooms) and dietary supplements. Many of these compounds are degraded and/or transformed as they pass through the digestive tract and most of them are excreted. Due to these reasons, finding new transport and delivery systems for antioxidants is an up-to-date research direction with immediate benefits. Moreover, the modulation process of the microbiota fingerprint represents an interesting way of enhancing the functional properties and bioavailability of certain bioactive compounds. These aspects are important for large groups of the population affected by chronic diseases and potentiate the classic medication.

In this Special Issue, called "Delivery Systems on the Antioxidant Activity of Natural Bioactive Compounds", authors are invited to present original research articles, review papers, clinical case reports, or communications.

Dr. Florentina Gatea
Prof. Dr. Emanuel Vamanu
Guest Editors

Manuscript Submission Information

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Keywords

  • natural extracts
  • bioavailability
  • modulation
  • delivery system for antioxidants
  • antioxidants
  • biodisponibility
  • oxidative stress

Published Papers (1 paper)

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Research

14 pages, 4092 KiB  
Article
A Facile Synthesis of Flower-like Iron Oxide Nanoparticles and Its Efficacy Measurements for Antibacterial, Cytotoxicity and Antioxidant Activity
by Nazish Tabassum, Virendra Singh, Vivek K. Chaturvedi, Emanuel Vamanu and Mohan P. Singh
Pharmaceutics 2023, 15(6), 1726; https://doi.org/10.3390/pharmaceutics15061726 - 14 Jun 2023
Cited by 3 | Viewed by 1250
Abstract
The objective of this study was to investigate the rhombohedral-structured, flower-like iron oxide (Fe2O3) nanoparticles that were produced using a cost-effective and environmentally friendly coprecipitation process. The structural and morphological characteristics of the synthesized Fe2O3 nanoparticles [...] Read more.
The objective of this study was to investigate the rhombohedral-structured, flower-like iron oxide (Fe2O3) nanoparticles that were produced using a cost-effective and environmentally friendly coprecipitation process. The structural and morphological characteristics of the synthesized Fe2O3 nanoparticles were analyzed using XRD, UV-Vis, FTIR, SEM, EDX, TEM, and HR-TEM techniques. Furthermore, the cytotoxic effects of Fe2O3 nanoparticles on MCF-7 and HEK-293 cells were evaluated using in vitro cell viability assays, while the antibacterial activity of the nanoparticles against Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae) was also tested. The results of our study demonstrated the potential cytotoxic activity of Fe2O3 nanoparticles toward MCF-7 and HEK-293 cell lines. The antioxidant potential of Fe2O3 nanoparticles was evidenced by the 1,1-diphenyl-2-picrylhydrazine (DPPH) and nitric oxide (NO) free radical scavenging assays. In addition, we suggested that Fe2O3 nanoparticles could be used in various antibacterial applications to prevent the spread of different bacterial strains. Based on these findings, we concluded that Fe2O3 nanoparticles have great potential for use in pharmaceutical and biological applications. The effective biocatalytic activity of Fe2O3 nanoparticles recommends its use as one of the best drug treatments for future views against cancer cells, and it is, therefore, recommended for both in vitro and in vivo in the biomedical field. Full article
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