Special Issue "The Role of Natural Products on Diabetes Mellitus Treatment, 2nd Edition"
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 1235
Special Issue Editors
Interests: drug delivery systems; pharmacokinetics; bioavailability; microparticles; nanoparticles; self-emulsifying delivery systems; extracts standardization
Special Issues, Collections and Topics in MDPI journals
Interests: endocrine physiology; male reproduction; diabetes; hormone action mechanism; natural products and analogues; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to the secretion and/or action of insulin. This disease of high incidence and prevalence affects the quality of life and productivity of the population that suffers from it. Although there are drugs that have been widely used in the treatment of this disease, at present the search for possible antidiabetic agents continues, especially for those that have more than one mechanism of action, taking into account the complexity of this pathology.
Metformin (a biguanide), which is a derivative of galegin, is among the first-line therapies for the treatment of type II DM. This guanidine was isolated from Galega officinalis L., a plant that has been used since the Middle Ages by diabetic patients. This fact has aroused interest in the use of medicinal plants and their secondary metabolites as possible drugs in DM treatment. Although it is difficult to find a substitute for insulin among plants, it is possible that molecules can be found that stimulate endogenous insulin biosynthesis and secretion or increase glucose absorption in blood by peripheral tissues, by acting as insulinomimetic or insulin secretagogic agents.
Following on from the above, this second edition of the Special Issue is focused on the study of natural products (characterized extracts and isolated secondary metabolites) in the treatment of diabetes mellitus complications by in vivo and in vitro assays. Clinical trials are also welcome.
Prof. Dr. Diana Marcela Aragon Novoa
Prof. Dr. Fátima Regina Mena Barreto Silva
Guest Editors
Manuscript Submission Information
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Keywords
- diabetes mellitus
- natural products
- secondary metabolites
- insulin secretagogue
- oxidative stress
- insulin response
- blood glucose levels
- hyperglycemia
- insulinomimetic
