Research Progress of Nanomedicine and Its Pharmacokinetics

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".

Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 2780

Special Issue Editors


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Guest Editor
MINT, INSERM U1066, CNRS UMR 6021, SFR ICAT, University of Angers, F-49000 Angers, France
Interests: nanomedicine; physiological-based pharmacokinetics (PBPK); population pharmacokinetics (popPK)

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Guest Editor
INSERM U1066-CNRS 6021, Micro et Nanomédecines Translationnelles, Université d′Angers, Angers, France
Interests: nanomedicine; physiological-based pharmacokinetics (PBPK); population pharmacokinetics (popPK)

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Guest Editor
Department of Pharmacy and Biotechnology, University of Bologna, 40127 Bologna, Italy
Interests: drug delivery; pharmaceutical nanotechnology; nanomedicine; pulmonary drug delivery; cell encapsulation; tissue engineering
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Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute to a Special Issue of the peer-reviewed, open-access journal Pharmaceutics, which will be devoted to “Research progress of nanomedicine and its pharmacokinetics”. Nanomedicines are mainly designed to enhance the oral bioavailability of a drug, improve its targeting, or control its release. Consequently, it is now well known that nanomedicines modify the pharmacokinetics profile of a drug. Recently, new methods for the detection and the quantitation of nanomedicines in vitro and in vivo have been described, which allow to precisely determine the pharmacokinetics profile of the nanocarrier itself, in addition to the drug. However, it seems that classical pharmacokinetics models are not sufficient to describe the pharmacokinetics profile of nanomedicines. An accurate pharmacokinetics evaluation and modeling of nanomedicines will help them reach clinical evaluations and then the market, changing the fate of numerous diseases.

This Special Issue encourages scientists and researchers to publish their experimental results in order to capture the current state of the art in this trendy research area. All data concerning the absorption, distribution, and elimination but also physiological-based pharmacokinetics (PBPK) and population pharmacokinetics (popPK) studies of nanomedicines are encouraged.

Globally, all original research articles and reviews, including the pharmacokinetics of organic and inorganic nanomedicines, are welcome.

We look forward to receiving your contribution.

Dr. Samuel Legeay
Dr. Lebreton Vincent
Dr. Paolo Blasi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • physiological-based pharmacokinetics (PBPK)
  • population pharmacokinetics (popPK)

Published Papers (1 paper)

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Review

15 pages, 4195 KiB  
Review
Microbubble Delivery Platform for Ultrasound-Mediated Therapy in Brain Cancers
by Kibeom Kim, Jungmin Lee and Myoung-Hwan Park
Pharmaceutics 2023, 15(2), 698; https://doi.org/10.3390/pharmaceutics15020698 - 19 Feb 2023
Cited by 3 | Viewed by 2394
Abstract
The blood-brain barrier (BBB) is one of the most selective endothelial barriers that protect the brain and maintains homeostasis in neural microenvironments. This barrier restricts the passage of molecules into the brain, except for gaseous or extremely small hydrophobic molecules. Thus, the BBB [...] Read more.
The blood-brain barrier (BBB) is one of the most selective endothelial barriers that protect the brain and maintains homeostasis in neural microenvironments. This barrier restricts the passage of molecules into the brain, except for gaseous or extremely small hydrophobic molecules. Thus, the BBB hinders the delivery of drugs with large molecular weights for the treatment of brain cancers. Various methods have been used to deliver drugs to the brain by circumventing the BBB; however, they have limitations such as drug diversity and low delivery efficiency. To overcome this challenge, microbubbles (MBs)-based drug delivery systems have garnered a lot of interest in recent years. MBs are widely used as contrast agents and are recently being researched as a vehicle for delivering drugs, proteins, and gene complexes. The MBs are 1–10 μm in size and consist of a gas core and an organic shell, which cause physical changes, such as bubble expansion, contraction, vibration, and collapse, in response to ultrasound. The physical changes in the MBs and the resulting energy lead to biological changes in the BBB and cause the drug to penetrate it, thus enhancing the therapeutic effect. Particularly, this review describes a state-of-the-art strategy for fabricating MB-based delivery platforms and their use with ultrasound in brain cancer therapy. Full article
(This article belongs to the Special Issue Research Progress of Nanomedicine and Its Pharmacokinetics)
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