Special Issue "Methods and Delivery Systems for Improving Drug Bioavailability"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 208

Special Issue Editors

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Interests: nanocarriers; topical drug delivery systems; dermal absorption; skin models; in vitro studies; nanomedicine; transdermal delivery; transmucosal delivery; cronocosmetic; skin biodistribution
Special Issues, Collections and Topics in MDPI journals
1. Institut de Nanociència i Nanotecnologia IN2UB, Universitat de Barcelona, 08028 Barcelona, Spain
2. Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Interests: materials chemistry; bioconjugation; nanochemistry; nanostructured formulations; nanocarriers; dermal delivery; mucosal delivery; topical drug delivery; permeation studies; drug release studies

Special Issue Information

Dear Colleagues,

The efficacy of drugs is often limited by their physicochemical properties such as very low or very high water solubility, leading to low absorption and thus low ability to reach systemic circulation. As well, their efficacy might be limited by their pharmacokinetic profile, encountering problems for reaching their therapeutic target at sufficient concentration and time.

To counteract these limitations, several strategies have been developed, including novel formulation systems based on micro- or nanostructured materials, which aim to increase drug stability and absorption, and can provide a controlled drug release, modifying the biopharmaceutical and pharmacokinetic profile. Formulations can be designed for oral delivery or for other routes of administration such as topical application (including transdermal, buccal, and sublingual mucosae), which avoid the first pass metabolism, and therefore increase drug bioavailability. As well, mechanically assisted techniques, such as microneedles, permit creating microchannels through the skin, through which the drug can permeate at a higher speed and to a higher extent. Finally, other mechanically assisted techniques such as ultrasound-stimulated microbubbles (cavitation) can help disrupt tissues such as the blood-brain barrier to permit the permeation of drugs to the Central Nervous System.

This special issue will cover topics including the design, development and characterization of new formulation systems, including nanostructured and microstructured materials, for oral or other routes of administration, mechanically-assisted techniques, or biopharmaceutic and pharmacokinetic studies, to show the progress achieved in improving the bioavailability of drugs.

This special issue is open for original research and review articles. We look forward to receiving your contributions.

Dr. Mireia Mallandrich
Dr. David Limón
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • drug delivery systems
  • bioavailability
  • formulation
  • nanomaterials
  • hydrogels
  • nanoparticles
  • microspheres
  • microparticles
  • in vitro testing
  • in vivo testing
  • biopharmaceutical studies
  • pharmacokinetic studies

Published Papers

There is no accepted submissions to this special issue at this moment.
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