Special Issue "Mesoporous Materials for Biomedical Application"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 15 August 2023 | Viewed by 500

Special Issue Editor

Polymer Department, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania
Interests: nanostructured polymers and composites; mesoporous (bio)materials; metallic particles; functionalized nanoparticles; hybrid micro/nanoparticles with controlled properties; host–guest systems; hybrid magnetic–polymer nanoparticles; porous clay heterostructures; (micro)encapsulation/controlled release of (bio)active substances; sol–gel process; emulsion and microemulsion polymerization
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Special Issue Information

Dear Colleagues,

Mesoporous materials, especially those made of silica, are capturing great interest in the field of nanomedicine, and are intended for both systemic delivery systems and implantable local-delivery devices. In general, mesoporous materials are derived from supramolecular assemblies of surfactants, which template the inorganic component during synthesis. After the surfactant is removed, commonly by pyrolysis or dissolution with the appropriate solvent, the mesoporous matrices are potential drug carriers. Due to their unique pore size, higher surface area and pore volume, mesoporous materials have been widely employed as carriers for controlled drug delivery.

This Special Issue of Pharmaceutics is therefore dedicated to the most recent advances regarding the use of mesoporous materials in the field of biomedical applications.

Given your interesting work on the theme and related disciplines, I personally invite you and your colleagues to contribute either an original research paper or a review, to be published as an invited feature paper to this Special Issue. Research areas may include (but are not limited to) the following: devices based on mesoporous materials related to drugs and drug delivery; controlled-release mesoporous materials for drugs and (bio)pharmaceuticals; nanomedicine; drug targeting; and pharmaceutical formulation.

I look forward to receiving your contributions.

Dr. Cristina Nistor
Guest Editor

Manuscript Submission Information

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Keywords

  • mesoporous materials
  • drug delivery
  • drug nanocarriers
  • mesoporous nanoparticles
  • biocompatible materials
  • controlled drug delivery formulations
  • porosity

Published Papers (1 paper)

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Research

Article
Kinetics and Mechanism of Camptothecin Release from Transferrin-Gated Mesoporous Silica Nanoparticles through a pH-Responsive Surface Linker
Pharmaceutics 2023, 15(6), 1590; https://doi.org/10.3390/pharmaceutics15061590 - 25 May 2023
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Abstract
Stimuli-responsive nanomaterials have emerged as a promising strategy for inclusion in anticancer therapy. In particular, pH-responsive silica nanocarriers have been studied to provide controlled drug delivery in acidic tumor microenvironments. However, the intracellular microenvironment that the nanosystem must face has an impact on [...] Read more.
Stimuli-responsive nanomaterials have emerged as a promising strategy for inclusion in anticancer therapy. In particular, pH-responsive silica nanocarriers have been studied to provide controlled drug delivery in acidic tumor microenvironments. However, the intracellular microenvironment that the nanosystem must face has an impact on the anticancer effect; therefore, the design of the nanocarrier and the mechanisms that govern drug release play a crucial role in optimizing efficacy. Here, we synthesized and characterized mesoporous silica nanoparticles with transferrin conjugated on their surface via a pH-sensitive imine bond (MSN-Tf) to assess camptothecin (CPT) loading and release. The results showed that CPT-loaded MSN-Tf (MSN-Tf@CPT) had a size of ca. 90 nm, a zeta potential of −18.9 mV, and a loaded content of 13.4%. The release kinetic data best fit a first-order model, and the predominant mechanism was Fickian diffusion. Additionally, a three-parameter model demonstrated the drug-matrix interaction and impact of transferrin in controlling the release of CPT from the nanocarrier. Taken together, these results provide new insights into the behavior of a hydrophobic drug released from a pH-sensitive nanosystem. Full article
(This article belongs to the Special Issue Mesoporous Materials for Biomedical Application)
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