Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Advanced Strategies for Sublingual and Buccal Drug Delivery
share announcement

Advanced Strategies for Sublingual and Buccal Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2058

Special Issue Editors

Dr. Hassan Almoazen

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
Interests: design and evaluate pediatric dosage forms; enhance solubility and dissolution rate of poorly soluble drugs; enhance stability of nanosuspensions; design microemulsions and nanoemulsions for the transdermal delivery of ions and small molecules
Special Issues, Collections and Topics in MDPI journals
Dr. Claire Monge

E-Mail Website
Guest Editor
Tissue Biology and Therapeutic Engineering Laboratory, Institute of Biology and Chemistry of Proteins, UMR 5305, CNRS/University Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France
Interests: seaweed; sulfated polysaccharide; respiratory virus; approved antivirals; antiviral activity; vaccine; vaccine adjuvant; sublingual
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the past several years, we have witnessed a remarkable interest in sublingual and buccal drug delivery systems. The sublingual route is very attractive for low-dose therapeutic agents and drugs for emergency use such as pain reduction, acute angina pectoris, opioid addiction, and anaphylactic shock. The route has also been favorable for pediatric formulations since young children are unable to swallow tablets or capsules. The physiology of sublingual absorption provides an alternative to oral absorption for low-dose small molecules, peptides, or even proteins that are prone to degradation in the gastric intestinal tract. Potentially, this route can also be feasible for vaccines and other peptides and proteins delivered at very low doses with the help of solid lipid nano particles or other penetration enhancers. 

The purpose of this Special Issue of Pharmaceutics is to draw attention to the importance of sublingual and buccal delivery systems and to provide scientists with a platform to publish their novel research work in this area. 

This Special Issue seeks novel topics pertaining to “Advanced Strategies for Sublingual and Buccal Drug Delivery”. Original research as well as reviews will be considered for publication.

We look forward to receiving your contributions.

Dr. Hassan Almoazen
Dr. Claire Monge
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • permeability enhancement
  • sublingual absorption
  • buccal absorption
  • fast-dissolving film
  • fast-dissolving tablet
  • under the tongue solution spray
  • prodrugs design
  • pediatric formulations
  • drug stability
  • drug solubility
  • microneedle sublingual patch
  • microneedle buccal patch
  • solid lipid nanoparticles
  • nanoemulsion
  • nanosuspension
  • colloidal dispersion

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

38 pages, 8570 KiB  
Article
Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling
by Marina-Theodora Talianu, Cristina-Elena Dinu-Pîrvu, Mihaela Violeta Ghica, Valentina Anuţa, Răzvan Mihai Prisada and Lăcrămioara Popa
Pharmaceutics 2024, 16(2), 271; https://doi.org/10.3390/pharmaceutics16020271 - 14 Feb 2024
Viewed by 889
Abstract
This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its [...] Read more.
This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its bioavailability. The formulation and preparation process was combined with a mathematical approach using a 23-full factorial plan. Fluid and gel-like microemulsions were obtained and analyzed considering pH, conductivity, and refractive index, followed by extensive analyses focused on droplet size, zeta potential, rheological behavior, and goniometry. In vitro release tests were performed to assess their biopharmaceutical characteristics. Independent variables coded X1-Oleic acid (%, w/w), X2-Tween 20 (%, w/w), and X3-PEG 400 (%, w/w) were analyzed in relationship with three main outputs like mean droplet size, work of adhesion, and diffusion coefficient by combining statistical tools with response surface methodology. The microemulsion containing miconazole base–2%, oleic acid–5%, Tween 20–40%, PEG 400–20%, and water–33% exhibited a mean droplet size of 119.6 nm, a work of adhesion of 71.98 mN/m, a diffusion coefficient of 2.11·10−5 cm2/s, and together with remarked attributes of two gel-like systems formulated with higher oil concentrations, modeled the final optimization step of microemulsions as potential systems for buccal delivery. Full article
(This article belongs to the Special Issue Advanced Strategies for Sublingual and Buccal Drug Delivery)
►▼ Show Figures

Graphical abstract

14 pages, 2775 KiB  
Article
Permeation Protection by Waterproofing Mucosal Membranes
by Luisa Coderch, Cristina Alonso, Ana Cristina Calpena, Maria Luisa Pérez-García, Beatriz Clares-Naveros, Anderson Ramos and Meritxell Martí
Pharmaceutics 2023, 15(12), 2698; https://doi.org/10.3390/pharmaceutics15122698 - 29 Nov 2023
Viewed by 729
Abstract
The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability depends mainly on the thickness and keratinization degree of the tissues. Their permeability barrier is conditioned by the presence of certain lipids. This work has the [...] Read more.
The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability depends mainly on the thickness and keratinization degree of the tissues. Their permeability barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the barrier effect of oral mucosa with a series of formulations to reduce permeation. Transmembrane water loss of different formulations was evaluated, and three of them were selected to be tested on the sublingual mucosa permeation of drugs. Caffeine, ibuprofen, dexamethasone, and ivermectin were applied on porcine skin, mucosa, and modified mucosa in order to compare the effectiveness of the formulations. A similar permeation profile was obtained in the different membranes: caffeine > ibuprofen~dexamethasone > ivermectin. The most efficient formulation was a liposomal formulation composed of lipids that are present in the skin stratum corneum. Impermeability provided by this formulation was notable mainly for the low-molecular-weight compounds, decreasing their permeability coefficient by between 40 and 80%. The reinforcement of the barrier function of mucosa provides a reduction or prevention of the permeation of different actives, which could be extrapolated to toxic compounds such as viruses, contaminants, toxins, etc. Full article
(This article belongs to the Special Issue Advanced Strategies for Sublingual and Buccal Drug Delivery)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop