Special Issue "Innovative Strategies for Glutathione Depletion in Cancer Therapy"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: 10 November 2023 | Viewed by 664

Special Issue Editors

Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
Interests: nanomedicine; biomaterials
Special Issues, Collections and Topics in MDPI journals
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Interests: development of targeted drug delivery systems for neurodegenerative diseases and cancer therapy
Special Issues, Collections and Topics in MDPI journals

Guest Editor
DWI-Leibniz-Institute for Interactive Materials e.V., Forckenbeckstr. 50, 52074 Aachen, Germany
Interests: biomedicine; nanotheranostics; exogpharmacology; smart micro/nanogels
Department of Orthopedics, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany
Interests: nanomedicine; advanced bio-/nano materials for cancer theranostics; cancer imaging; regenerative medicine; bone defect and healing; cell biology-inspired tissue regeneration; bone regenerative scaffolds

Special Issue Information

Dear Colleagues,

Glutathione (GSH) is an important member of the cellular antioxidative system. In cancer cells, a high GSH level is indispensable for scavenging excessive reactive oxygen species (ROS) and detoxifying xenobiotics, making it a potential target for cancer therapy. Many studies have shown that a loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proven to enhance the therapeutic efficacy of ROS-based therapies (photodynamic, sonodynamic, and chemodynamic therapy), ferroptosis, and chemotherapy. Intractable challenges regarding GSH depletion and metabolism are ongoing in the field of cancer therapy, and there is growing evidence that GSH is a dominant factor in the development and progression of malignant tumors.

GSH depletion based on the multi-strategy of simultaneously inhibiting upstream GSH synthesis and consuming downstream GSH reserves may be a promising solution. Furthermore, being aware of the mechanism behind each strategy is especially important for choosing the proper approach to GSH depletion and enhancing the efficacy of cancer therapy. Functional materials or medications with GSH-consuming abilities are of particular interest due to their unique advantages and potential. Thus, our Special Issue focuses on elucidating the innovative strategies of GSH depletion in cancer diagnostics, treatment, and prognostics, which require deep exploration.

The aim of this Special Issue is to collect high-quality original research and review articles on recent progress in the ingenious application of GSH-depleting strategies in cancer therapy for improving the outcomes of various therapeutic regimens.

Potential topics include, but are not limited to:

  1. Elucidation of the mechanisms of crosstalk between tumor cell death, immunity, and GSH depletion in different pathologies.
  2. Novel delivery systems for chemicals targeting regulated GSH and oxidative stress.
  3. New diagnostic and therapeutic strategies targeting regulated cellular GSH content.
  4. The roles of GSH depletion in various therapeutic modalities such as radiotherapy, chemotherapy, and phototherapy.
  5. The identification of novel findings on key factors (such as genetic and metabolic aspects) in tumor GSH depletion.
  6. Chemically induced GSH depletion in the treatment of cancer.
  7. The inhibition of GSH biosynthesis.
  8. Boosting nanotherapeutics by depleting intracellular GSH.
  9. Depleting mitochondrial GSH (mtGSH) for cancer therapy.
  10. Clinical trials of GSH-depletion-enhanced cancer therapy.

Dr. Daoming Zhu
Dr. Tongkai Chen
Dr. Xin Li
Dr. Xing Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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