Editorial Board Members’ Collection Series: Development and Pharmaceutical Applications of Protein-Based Advanced Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 5452

Special Issue Editors


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Guest Editor
Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus "S. Venuta", Building of BioSciences, I-88100 Catanzaro, Italy
Interests: drug delivery; liposomes; pharmaceutical technology; polymeric micro/nanoparticles; selective targeting
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Guest Editor
Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra d’Oltremare Pad.20, V.le J.F. Kennedy 54, 80125 Naples, Italy
Interests: biomaterials; scaffolds; electrospinning; electrospraying; hydrogel atomization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, proteins have been investigated as excellent natural building blocks for the development of drug delivery systems with the aim of modulating the pharmacokinetic and pharmacodynamic characteristics of various active compounds. This is due to their unique properties such as wide availability, high biocompatibility, biodegradability, cost-effectiveness and potential fast regulatory approval processes.

Unfortunately, much criticism has been described during the development of various formulations as a consequence of the manufacturing procedures and the heterogeneous mixture of different molecular weights of proteins that cause a significant batch-to-batch variation. For this reason, innovative approaches and specific techniques have been proposed in order to address these issues and to better exploit the use of these biopolymers for pharmaceutical applications.

The aim of this Special Issue is to describe the latest investigations related to i) the development and characterization of novel protein-based systems proposed as drug carriers, ii) the modulation of the structural properties and the surface architecture of colloidal systems able to target specific cells and tissues, and iii) the advancement provided by the association of proteins to biocompatible molecules (lipids, saccharides, and other polymers) in order to obtain micro/nanoblends with useful technological features.

Original research papers, communication papers, and review articles focused on the description of the aforementioned topics are all welcome.

Dr. Donato Cosco
Dr. Vincenzo Guarino
Guest Editors

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Published Papers (2 papers)

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Research

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14 pages, 2517 KiB  
Article
Gliadin Nanoparticles Containing Doxorubicin Hydrochloride: Characterization and Cytotoxicity
by Silvia Voci, Agnese Gagliardi, Nicola Ambrosio, Maria Cristina Salvatici, Massimo Fresta and Donato Cosco
Pharmaceutics 2023, 15(1), 180; https://doi.org/10.3390/pharmaceutics15010180 - 04 Jan 2023
Cited by 4 | Viewed by 1382
Abstract
Doxorubicin hydrochloride (DOX) is a well-known antitumor drug used as first line treatment for many types of malignancies. Despite its clinical relevance, the administration of the compound is negatively affected by dose-dependent off-target toxicity phenomena. Nanotechnology has helped to overcome these important limitations [...] Read more.
Doxorubicin hydrochloride (DOX) is a well-known antitumor drug used as first line treatment for many types of malignancies. Despite its clinical relevance, the administration of the compound is negatively affected by dose-dependent off-target toxicity phenomena. Nanotechnology has helped to overcome these important limitations by improving the therapeutic index of the bioactive and promoting the translation of novel nanomedicines into clinical practice. Herein, nanoparticles made up of wheat gliadin and stabilized by polyoxyethylene (2) oleyl ether were investigated for the first time as carriers of DOX. The encapsulation of the compound did not significantly affect the physico-chemical features of the gliadin nanoparticles (GNPs), which evidenced a mean diameter of ~180 nm, a polydispersity index < 0.2 and a negative surface charge. The nanosystems demonstrated great stability regarding temperature (25–50 °C) and were able to retain high amounts of drug, allowing its prolonged and sustained release for up to a week. In vitro viability assay performed against breast cancer cells demonstrated that the nanoencapsulation of DOX modulated the cytotoxicity of the bioactive as a function of the incubation time with respect to the free form of the drug. The results demonstrate the potential use of GNPs as carriers of hydrophilic antitumor compounds. Full article
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24 pages, 1442 KiB  
Review
Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
by Keisheni Ganeson, Cindy Tan Xue May, Amirul Al Ashraf Abdullah, Seeram Ramakrishna and Sevakumaran Vigneswari
Pharmaceutics 2023, 15(9), 2356; https://doi.org/10.3390/pharmaceutics15092356 - 20 Sep 2023
Cited by 3 | Viewed by 3581
Abstract
Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their properties because of external [...] Read more.
Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their properties because of external stimuli. However, protein-based smart materials allow modular protein domains with different functionalities and responsive behaviours to be easily combined. Wherein, these “smart” behaviours can be tuned by amino acid identity and sequence. This review aims to give an insight into the design of smart materials, mainly protein-based piezoelectric materials, shape-memory materials, and hydrogels, as well as highlight the current progress and challenges of protein-based smart materials in tissue engineering. These materials have demonstrated outstanding regeneration of neural, skin, cartilage, bone, and cardiac tissues with great stimuli-responsive properties, biocompatibility, biodegradability, and biofunctionality. Full article
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