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6.9
5.4
Journals
Pharmaceutics
Special Issues
New Insights into Transporters in Drug Development
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New Insights into Transporters in Drug Development

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 2312

Special Issue Editors

Dr. Sook Wah Yee

E-Mail Website
Guest Editor
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA
Interests: pharmacogenomics; membrane transporters; orphan transporter
Dr. Hong Shen

E-Mail Website
Guest Editor
Department of Drug Metabolism and Pharmacokinetics (DMPK), Bristol Myers Squibb, Princeton, NJ, USA
Interests: transporter biomarkers; drug transporters; pharmacokinetics

Special Issue Information

Dear Colleagues,

You're invited to submit an article for a Special Issue on “New Insights into Transporters in Drug Development”. As a respected leader in this field, your expertise would make a valuable contribution to this Special Issue.

The Special Issue aims to highlight the recent advances in the research on transporters and their role in drug development. Original research articles, reviews, and perspectives are welcome on topics including, but not limited to, the following:

  • Endogenous biomarkers for drug transporters;
  • Transporter proteomics-based in vitro-to-in vivo extrapolation;
  • Physiologically-based pharmacokinetic models for predicting transporter-mediated drug interactions;
  • Computational and experimental approaches to identify transporter ligands, substrates, and inhibitors;
  • Resources and tools relevant to transporters in drug development;
  • Clinical implications of transporter-mediated drug disposition and response.

Your contribution to this important topic is eagerly anticipated.

Sincerely,

Dr. Sook Wah Yee
Dr. Hong Shen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • membrane transporters
  • drug–drug interactions
  • in vitro-to-in vivo extrapolation
  • transporters as therapeutic targets
  • regulation of transporter expression and activity

Published Papers (2 papers)

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Review

16 pages, 937 KiB  
Review
Impact of Drug-Mediated Inhibition of Intestinal Transporters on Nutrient and Endogenous Substrate Disposition…an Afterthought?
by Kshitee Kharve, Andrew S. Engley, Mary F. Paine and Jason A. Sprowl
Pharmaceutics 2024, 16(4), 447; https://doi.org/10.3390/pharmaceutics16040447 - 24 Mar 2024
Viewed by 592
Abstract
A large percentage (~60%) of prescription drugs and new molecular entities are designed for oral delivery, which requires passage through a semi-impervious membrane bilayer in the gastrointestinal wall. Passage through this bilayer can be dependent on membrane transporters that regulate the absorption of [...] Read more.
A large percentage (~60%) of prescription drugs and new molecular entities are designed for oral delivery, which requires passage through a semi-impervious membrane bilayer in the gastrointestinal wall. Passage through this bilayer can be dependent on membrane transporters that regulate the absorption of nutrients or endogenous substrates. Several investigations have provided links between nutrient, endogenous substrate, or drug absorption and the activity of certain membrane transporters. This knowledge has been key in the development of new therapeutics that can alleviate various symptoms of select diseases, such as cholestasis and diabetes. Despite this progress, recent studies revealed potential clinical dangers of unintended altered nutrient or endogenous substrate disposition due to the drug-mediated disruption of intestinal transport activity. This review outlines reports of glucose, folate, thiamine, lactate, and bile acid (re)absorption changes and consequent adverse events as examples. Finally, the need to comprehensively expand research on intestinal transporter-mediated drug interactions to avoid the unwanted disruption of homeostasis and diminish therapeutic adverse events is highlighted. Full article
(This article belongs to the Special Issue New Insights into Transporters in Drug Development)
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17 pages, 1398 KiB  
Review
Multiple Regulatory Signals and Components in the Modulation of Bicarbonate Transporters
by Hyeong Jae Kim and Jeong Hee Hong
Pharmaceutics 2024, 16(1), 78; https://doi.org/10.3390/pharmaceutics16010078 - 05 Jan 2024
Viewed by 1116
Abstract
Bicarbonate transporters are responsible for the appropriate flux of bicarbonate across the plasma membrane to perform various fundamental cellular functions. The functions of bicarbonate transporters, including pH regulation, cell migration, and inflammation, are highlighted in various cellular systems, encompassing their participation in both [...] Read more.
Bicarbonate transporters are responsible for the appropriate flux of bicarbonate across the plasma membrane to perform various fundamental cellular functions. The functions of bicarbonate transporters, including pH regulation, cell migration, and inflammation, are highlighted in various cellular systems, encompassing their participation in both physiological and pathological processes. In this review, we focused on recently identified modulatory signaling components that regulate the expression and activity of bicarbonate transporters. Moreover, we addressed recent advances in our understanding of cooperative systems of bicarbonate transporters and channelopathies. This current review aims to provide a new, in-depth understanding of numerous human diseases associated with the dysfunction of bicarbonate transporters. Full article
(This article belongs to the Special Issue New Insights into Transporters in Drug Development)
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