Special Issue "Essential Oil in Pharmaceutical Products for the Management of Chronic Diseases"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 July 2023 | Viewed by 593

Special Issue Editor

Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy
Interests: essential oils; inflammation; cancer; chronic disorders

Special Issue Information

Dear Colleagues,

Pharmaceutics is planning a Special Issue focusing on Essential Oils (EO) and their possible use in pharmaceutical products for the prevention or treatment of chronic disorders, including cancer. There is rising evidence of the efficacy of EOs and/or their single components for the treatment of several human disorders; regardless, scientific knowledge is still lacking about their biological proprieties or their mechanism of action at a cellular level. Moreover, their use on humans at therapeutic doses require to face with issues related to their pharmacokinetics, formulation, and toxicology. The aim of this Special Issue is to identify EOs or their single compounds as possible therapeutic agents, clarifying their biologic proprieties, their molecular and cellular mechanism of action, and the real possibility of their administration on humans, in order to provide a rationale for their use alone or in combination with other standard therapies.

Dr. Maria Chiara Valerii
Guest Editor

Manuscript Submission Information

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Keywords

  • essential oils
  • inflammation
  • cancer
  • chronic disorders

Published Papers (1 paper)

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Research

Article
Anti-Inflammatory Effects of Essential Oils from the Peels of Citrus Cultivars
Pharmaceutics 2023, 15(6), 1595; https://doi.org/10.3390/pharmaceutics15061595 - 25 May 2023
Viewed by 353
Abstract
Citrus cultivars have remarkable health benefits, but only the anti-inflammatory activities of the major varieties have been studied. This study investigated the anti-inflammatory effects of various citrus cultivars and their active anti-inflammatory components. The essential oils of 21 citrus peels were extracted via [...] Read more.
Citrus cultivars have remarkable health benefits, but only the anti-inflammatory activities of the major varieties have been studied. This study investigated the anti-inflammatory effects of various citrus cultivars and their active anti-inflammatory components. The essential oils of 21 citrus peels were extracted via hydrodistillation using a Clevenger-type apparatus, and the chemical compositions of the essential oils were analyzed. D-Limonene was the most abundant constituent. To evaluate the anti-inflammatory effects of the citrus cultivars, the gene expression levels of an inflammatory mediator and proinflammatory cytokines were investigated. Among the 21 essential oils, those extracted from C. japonica and C. maxima exhibited superior anti-inflammatory activities, being able to inhibit the expression of the inflammatory mediators and proinflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 cells. The essential oils of C. japonica and C. maxima were distinguished into seven distinct constituents, α-pinene, myrcene, D-limonene, β-ocimene, linalool, linalool oxide, and α-terpineol, compared with other essential oils. The anti-inflammatory activities of the seven single compounds significantly inhibited the levels of inflammation-related factors. In particular, α-terpineol exhibited a superior anti-inflammatory effect. This study showed that the essential oils from C. japonica and C. maxima exhibit high anti-inflammatory activity. In addition, α-terpineol is an active anti-inflammatory compound that contributes to inflammatory responses. Full article
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