Special Issue "Polymorphism"
Deadline for manuscript submissions: 30 September 2023 | Viewed by 1027
Polymorphism, the property of a compound to crystallize in more than one distinct crystal form, plays an indispensable role in researching and developing pharmaceuticals, agrochemicals, materials, and food. Polymorphs exhibit different properties, such as crystal habit, solubility, dissolution rate, melting point, stability, mechanical properties, even bioavailability, which may influence the product quality. Therefore, the study of the behavior of polymorphs can provide a theoretical basis for selecting the optimal solid forms and serve in the polymorphic control and optimization of the products as a primary method. Recently, due to the progress in the crystal engineering for pharmaceutics, the multicomponent molecular crystals for the design of new-generation bioavailable drugs have been intensively applied. The development of this area gave a stimulus for the investigation of different aspects of the polymorphism of multicomponent systems. Revealing the similarity and differences between the properties of the polymorphic forms of the individual compounds and multicomponent systems will make a significant contribution to the understanding of the fundamental principles of the design of pharmaceutical materials with the desired characteristics.
I am happy to invite researchers involved in the field of polymorphism of pharmaceutical systems to present their high-quality results in this forum, which is freely available for open access and discussion. This Special Issue will cover multiple aspects connected with several pertinent topics, including but not limited to:
- Screening the polymorphic forms of drug compounds and multicomponent molecular crystals (drug–drug, drug–coformer) by different methods and approaches (crystallization from solvent(s), sublimation, lyophilization, mechanochemistry, slurry, crystallization from melt and so on).
- Analysis of the crystal structures (by single crystal X-ray) of polymorphic pharmaceutical systems (active pharmaceutical ingredients and their multicomponent crystals). Searching the regularities between the crystal structure characteristics and physicochemical properties/processes, which are important for the pharmaceutical industry: solubility, release, membrane permeability, phase transitions (including fusion processes of various modifications), thermodynamic stability, tabletting and so on.
- Theoretical calculations/evaluations (by various approaches) of the crystal lattice energies of different polymorphic forms and their relationship with the solubility characteristics and thermodynamic stability.
- In vivo and in vitro studies of polymorphic modifications.
Prof. Dr. German L. Perlovich
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- polymorphic forms
- multi-components molecular crystals
- thermodynamic stability
- phase transitions
- membrane permeability