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Pharmaceutics
Special Issues
New Approach to Anti-inflammation, Antibacterial and Anti-cancer Therapy: Natural Extracts
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New Approach to Anti-inflammation, Antibacterial and Anti-cancer Therapy: Natural Extracts

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 10 August 2024 | Viewed by 4041

Special Issue Editors

Dr. Mee-Hyun Lee

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Guest Editor
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
Interests: cancer; cell signaling; targeted therapy
Dr. Jun Lee

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Guest Editor
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine (KIOM), Naju 58245, Republic of Korea
Interests: herbal medicine; extraction; active component
Prof. Dr. Felicia-Gabriela Gligor

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Guest Editor
Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 2A Lucian Blaga St., 550169 Sibiu, Romania
Interests: natural products; antioxidants; dendrimers; drug delivery; analytical methods; biochemistry; laboratory tests; pharmacovigilance
Special Issues, Collections and Topics in MDPI journals
Dr. Cecilia Georgescu

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Guest Editor
Department of Agricultural Sciences and Food Engineering, Faculty of Agricultural Sciences, Food Industry and Environmental Protection, “Lucian Blaga” University of Sibiu, 7-9 Dr. I. Ratiu St., 550012 Sibiu, Romania
Interests: natural compounds; phytochemical analysis; antioxidant activity; volatile oils; food sciences
Dr. Claudiu Morgovan

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Guest Editor
Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 2A Lucian Blaga St., 550169 Sibiu, Romania
Interests: natural products; safety and effectiveness of health products; chronic diseases; pharmacovigilance; nutrivigilance; drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Carmen Maximiliana Dobrea

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Guest Editor
Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 2A Lucian Blaga St., 550169 Sibiu, Romania
Interests: natural products; antioxidants; phytochemicals; nutrivigilance; toxicology; dendrimers; drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Adina Frum

E-Mail Website
Guest Editor
Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 2A Lucian Blaga St., 550169 Sibiu, Romania
Interests: phytochemical analyses; antioxidants; polyphenols; environmental sciences; natural products; nutrivigilance; dendrimers; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although many natural extracts with anti-inflammation, antibacterial and anticancer effects have already been reported, we are still eager to discover new components and new applications. Cost-effective biological activities with less toxicity and less resistance are required through methods such as: 1) using diverse methods for extraction, 2) discovering the effective novel component, 3) regulating mechanisms such as the signal transduction, microbiome/metabolite, inflammation and apoptosis, and 4) modulating the delivery systems.

This Special Issue aims to cover the diverse range of natural extracts and their bioactive components from plants, marines, etc., for inflammation, antibacterial and cancer treatment in terms of molecular mechanisms and novel components. Articles including original research or reviews will be welcome and the topics are expected to focus on but are not limited to: (1) research on novel natural extracts or components for inflammation, bacterial and cancer; (2) new approaches for extractions; (3) the molecular mechanisms of natural extracts or active components, including signal transduction, inflammatory cytokines, and microbiome/metabolite-mediated regulation; and (4) apply for the pharmacokinetics, pharmacodynamics and delivery systems.

Dr. Mee-Hyun Lee
Dr. Jun Lee
Prof. Dr. Felicia-Gabriela Gligor
Dr. Cecilia Georgescu
Dr. Claudiu Morgovan
Dr. Carmen Maximiliana Dobrea
Dr. Adina Frum
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural extract
  • inflammation
  • bacterial
  • cancer
  • active component
  • signal transduction
  • microbiome
  • metabolite
  • apoptosis
  • delivery system
  • pharmacokinetics
  • pharmacodynamics

Published Papers (4 papers)

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Research

15 pages, 3654 KiB  
Article
An Integrative Study of Scrophularia takesimensis Nakai in an Ovalbumin-Induced Murine Model of Asthma: The Effect on T Helper 2 Cell Activation
by Yun-Soo Seo, Jun-Ho Song, Hyo Seon Kim, Hyeon Hwa Nam, Sungyu Yang, Goya Choi, Sung-Wook Chae, Jeongmin Lee, Bokyung Jung, Joong-Sun Kim and Inkyu Park
Pharmaceutics 2024, 16(4), 529; https://doi.org/10.3390/pharmaceutics16040529 - 12 Apr 2024
Viewed by 383
Abstract
Scrophularia have traditionally been used as herbal medicines to treat neuritis, sore throats, and laryngitis. In particular, S. takesimensis, a Korean endemic species with restricted distribution on Ulleung Island, holds significant resource and genetic value. However, its pharmacological properties have not been [...] Read more.
Scrophularia have traditionally been used as herbal medicines to treat neuritis, sore throats, and laryngitis. In particular, S. takesimensis, a Korean endemic species with restricted distribution on Ulleung Island, holds significant resource and genetic value. However, its pharmacological properties have not been thoroughly evaluated. Thus, we provide detailed morphological characteristics and genomic information for S. takesimensis in this study. Moreover, its pharmacological activity was evaluated in an ovalbumin-induced asthma rat model, using extracts of S. takesimensis roots (100 or 200 mg/kg). The distinguishing features of S. takesimensis from related species include the presence or absence of stem wings, leaf shape, and habitat. The chloroplast (cp) genome of this species is 152,420 bp long and exhibits a conserved quadripartite structure. A total of 114 genes were identified, which included 80 protein-coding genes, 30 transfer RNA (tRNA) genes, and 4 ribosomal RNA (rRNA) genes. The gene order, content, and orientation of the S. takesimensis cp genome was highly conserved and consistent with the general structure observed in S. buergeriana and S. ningpoensis cp genomes. Confirming the anti-inflammatory effects of S. takesimensis extract (STE) using an established mouse model of ovalbumin-induced asthma, we observed reduced asthmatic phenotypes, including inflammatory cell infiltration, mucus production, and suppression of T helper 2 (Th2) cell. Furthermore, STE treatment reduced Th2 cell activation and differentiation. This study underscores the medicinal value of S. takesimensis. The importance of preserving S. takesimensis was revealed and crucial insights were provided for further research on its utilization as a medicinal resource. Full article
(This article belongs to the Special Issue New Approach to Anti-inflammation, Antibacterial and Anti-cancer Therapy: Natural Extracts)
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19 pages, 5463 KiB  
Article
Preparation and Characterization of a Novel Salicin–Cyclodextrin Complex
by Adina Căta, Ioana Maria Carmen Ienaşcu, Adina Frum, Daniel Ursu, Paula Svera, Corina Orha, Gerlinde Rusu, Adriana Aurelia Chiș, Carmen Maximiliana Dobrea, Claudiu Morgovan and Oana-Raluca Pop
Pharmaceutics 2024, 16(3), 369; https://doi.org/10.3390/pharmaceutics16030369 - 06 Mar 2024
Viewed by 780
Abstract
Bioactive compounds extracted from plants can provide wide health benefits. However, some molecules have limited applications as pharmaceuticals due to their limited solubility, poor bioavailability, and low stability when exposed to environmental factors. Their integration in formulations that can deliver them to physiological [...] Read more.
Bioactive compounds extracted from plants can provide wide health benefits. However, some molecules have limited applications as pharmaceuticals due to their limited solubility, poor bioavailability, and low stability when exposed to environmental factors. Their integration in formulations that can deliver them to physiological targets while preserving their biological activity can enhance their usage in improving human health. This research provides a delivery system design to enhance the solubility, stability and to mask the bitter taste of salicin. Thus, a novel salicin-β-cyclodextrin complex was prepared and analyzed by X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, FTIR, Raman and UV-Vis spectroscopy. The analytical and computational methods provided clear and distinct evidence for inclusion of salicin within the β-cyclodextrin cavity and brought important findings for the characterization of the inclusion complex. The present study showed that salicin and β-cyclodextrin can form inclusion complexes, both in solution and in solid state, and that the inclusion of salicin in the cavity of β-cyclodextrin leads to the improvement of its solubility and stability. Thus, the study communicates both qualitative and quantitative knowledge about the preparation of a new salicin-β-cyclodextrin inclusion complex suggesting its potential applications in pharmaceutical industry and medical sciences, as formulations with better compliance for the patient, with increased bioavailability, and easier control of dosage. Full article
(This article belongs to the Special Issue New Approach to Anti-inflammation, Antibacterial and Anti-cancer Therapy: Natural Extracts)
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14 pages, 2255 KiB  
Article
Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion
by Sohi Kang, Hyun-Yong Kim, A Yeong Lee, Hyo Seon Kim, Jun Hong Park, Byeong Cheol Moon, Hyeon Hwa Nam, Sung-Wook Chae, Bokyung Jung, Changjong Moon, In Sik Shin, Joong Sun Kim and Yun-Soo Seo
Pharmaceutics 2023, 15(9), 2355; https://doi.org/10.3390/pharmaceutics15092355 - 20 Sep 2023
Cited by 2 | Viewed by 918
Abstract
Asthma is a pulmonary disease induced by the inhalation of aeroallergens and subsequent inappropriate immune responses. Camellia sinensis (L.) Kuntze has been evaluated as an effective antioxidant supplement produced from bioactive compounds, including flavonoids. In this study, we aimed to determine the effects [...] Read more.
Asthma is a pulmonary disease induced by the inhalation of aeroallergens and subsequent inappropriate immune responses. Camellia sinensis (L.) Kuntze has been evaluated as an effective antioxidant supplement produced from bioactive compounds, including flavonoids. In this study, we aimed to determine the effects of Camellia sinensis (L.) Kuntze extract (CE) on ovalbumin-induced allergic asthma. The components of CE were analyzed using high-performance liquid chromatography (HPLC) chromatogram patterns, and asthmatic animal models were induced via ovalbumin treatment. The antioxidant and anti-inflammatory effects of CE were evaluated using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), and nitric oxide (NO) assays. Seven compounds were detected in the CE chromatogram. In the ovalbumin-induced mouse model, CE treatment significantly decreased the inflammation index in the lung tissue. CE also significantly decreased eosinophilia and the production of inflammatory cytokines and OVA-specific IgE in animals with asthma. Collectively, our results indicate that CE has anti-inflammatory and antioxidant activities, and that CE treatment suppresses asthmatic progression, including mucin accumulation, inflammation, and OVA-specific IgE production. Full article
(This article belongs to the Special Issue New Approach to Anti-inflammation, Antibacterial and Anti-cancer Therapy: Natural Extracts)
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20 pages, 3627 KiB  
Article
Fermented Sprouts of Codonopsis lanceolata Suppress LPS-Induced Inflammatory Responses by Inhibiting NF-κB Signaling Pathway in RAW 264.7 Macrophages and CD1 Mice
by Seung-Hyuk Choi, So-Yeon Kim, Kyeong-Min Kim, Tamanna Jahan Mony, Ho Jung Bae, Min Seok Kim, Chan Ho Lee, Sun-Eun Choi, Sang Ho Lee and Se Jin Park
Pharmaceutics 2023, 15(7), 1793; https://doi.org/10.3390/pharmaceutics15071793 - 22 Jun 2023
Cited by 1 | Viewed by 1166
Abstract
The interest in bioconversion through fermentation of sprouts produced in smart farms is increasing due to their potential health benefits. Codonopsis lanceolata (CL) is reported to alleviate inflammatory conditions, but much research is still needed to determine which types and parts of CL [...] Read more.
The interest in bioconversion through fermentation of sprouts produced in smart farms is increasing due to their potential health benefits. Codonopsis lanceolata (CL) is reported to alleviate inflammatory conditions, but much research is still needed to determine which types and parts of CL are most effective. This study investigated the anti-inflammatory effects of a fermented extract of CL sprouts’ aerial part (F-CSA) against LPS-stimulated RAW 264.7 macrophages and mice. In the screening test, F-CSA showed the most substantial anti-inflammatory effect among several samples, containing the highest total flavonoids, tannins, and polyphenols. UPLC-ESI-Q/TOF-MS and HPLC analysis revealed that F-CSA had the highest amount of luteolin among all the CL samples analyzed. F-CSA reduced the release of inflammatory cytokines and mediators such as NO and PGE2 by inhibiting the expression levels of iNOS and COX-2 in LPS-stimulated macrophages. Further, we found that the anti-inflammatory effects of F-CSA were mediated by inhibiting the JNK/NF-κB signaling pathway. Moreover, F-CSA improved survival rates and reduced plasma levels of NO and IL-6 in CD1 mice stimulated with LPS. These findings suggest that F-CSA, which contains luteolin, can alleviate inflammation in LPS-induced RAW 264.7 cells and a CD1 mouse model by inhibiting the JNK/NF-κB signaling pathways. Full article
(This article belongs to the Special Issue New Approach to Anti-inflammation, Antibacterial and Anti-cancer Therapy: Natural Extracts)
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