Special Issue "Development of Lipid Nano-Pharmaceutical Formulations for Oral/Dermal/Transdermal Delivery"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 1329

Special Issue Editors

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Interests: drug delivery; lipid based formulations; vesicles formulations; solubility enhancement
Special Issues, Collections and Topics in MDPI journals
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Interests: drug delivery; oral formulation; controlled release systems; nanoparticles; novel drug delivery systems

Special Issue Information

Dear Colleagues,

In most cases, oral drug delivery is most preferred as it is convenient, non-invasive, and easy to incorporate into a patient's lifestyle. Nevertheless, several factors, including poor solubility, low dissolution rate, stability, and bioavailability of many dugs remain a constant challenge in achieving the desired therapeutic targets. The delivery of drugs must overcome various obstacles, including the acidic gastric environment and the presence of intestinal efflux and influx transporters.

On the other hand, dermal/transdermal drug delivery candidates have increased in recent years in response to the development of new and optimized approaches to improve local and systemic drug delivery. Dermal/transdermal delivery of drugs represents an effective method to deliver drugs directly to the site of action or to enhance treatment activity noninvasively. They circumvent the hepatic first passage and reduce toxicity. Several new technologies have opened up new horizons in this area and have emerged as attractive administration methods.

Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs.

This Special Issue is addressed to those authors who are currently engaged in research on the use of lipid-based formulations for the development of oral and dermal/transdermal drug delivery systems. Both research and review papers on oral and dermal/transdermal drug delivery systems are invited for this Special Issue.

This Special Issue aims to collect recent advances, developments, and future prospects on the design, development, characterization, and biological evaluation of lipid pharmaceutical formulations for oral/dermal/transdermal delivery, which may include but is not exclusively limited to articles on: dermal delivery; drug delivery systems; iontophoresis; liposomes; microneedles; nanocarriers; nanoemulsions; nanoparticles; nanostructured lipid carriers; niosomes; oral administration; permeation enhancers; polymeric nanoparticles; self-nanoemulsifying drug delivery systems; solid lipid nanoparticles; sonophoresis; transdermal delivery; vesicular systems.

Dr. Abdul Ahad
Dr. Yousef A. Bin Jardan
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • dermal delivery
  • drug delivery systems
  • iontophoresis
  • liposomes
  • microneedles
  • nanocarriers
  • nanoemulsions
  • nanoparticles
  • nanostructured lipid carriers
  • niosomes
  • oral administration
  • permeation enhancers
  • polymeric nanoparticles
  • self-nanoemulsifying drug delivery systems
  • solid lipid nanoparticles
  • sonophoresis
  • transdermal delivery
  • vesicular systems

Published Papers (1 paper)

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Formulation of Miconazole-Loaded Chitosan–Carbopol Vesicular Gel: Optimization to In Vitro Characterization, Irritation, and Antifungal Assessment
Pharmaceutics 2023, 15(2), 581; https://doi.org/10.3390/pharmaceutics15020581 - 08 Feb 2023
Cited by 1 | Viewed by 857
Miconazole nitrate (MN) is a poorly water-soluble and antifungal drug used for fungal infections. The present research work was designed to develop topical MN-loaded bilosomes (BSs) for the improvement of therapeutic efficacy. MZBSs were prepared by using the thin-film hydration method and further [...] Read more.
Miconazole nitrate (MN) is a poorly water-soluble and antifungal drug used for fungal infections. The present research work was designed to develop topical MN-loaded bilosomes (BSs) for the improvement of therapeutic efficacy. MZBSs were prepared by using the thin-film hydration method and further optimized by using the Box–Behnken statistical design (BBD). The optimized miconazole bilosome (MZBSo) showed nano-sized vesicles, a low polydispersity index, a high entrapment efficiency, and zeta potential. Further, MZBSo was incorporated into the gel using carbopol 934P and chitosan polymers. The selected miconazole bilosome gel (MZBSoG2) demonstrated an acceptable pH (6.4 ± 0.1), viscosity (1856 ± 21 cP), and spreadability (6.6 ± 0.2 cm2). Compared to MZBSo (86.76 ± 3.7%), MZBSoG2 showed a significantly (p < 0.05) slower drug release (58.54 ± 4.1%). MZBSoG2 was found to be a non-irritant because it achieved a score of zero (standard score) in the HET-CAM test. It also exhibited significant antifungal activity compared to pure MZ against Candida albicans and Aspergillus niger. The stability study results showed no significant changes after stability testing under accelerated conditions. MZ-loaded gels could serve as effective alternative carriers for improving therapeutic efficacy. Full article
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