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Pharmaceutics
Special Issues
Designing Nanomaterials for Drug Delivery and Cancer-Targeted Therapy
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Special Issue "Designing Nanomaterials for Drug Delivery and Cancer-Targeted Therapy"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 1 September 2023 | Viewed by 1089

Special Issue Editor

Dr. Cristina Mariana Uritu

E-Mail Website
Guest Editor
Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iași, 700115 Iași, Romania
Interests: drug delivery; gene therapy; biomaterials; nanotechnology; radiopharmaceuticals; radiotracers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is becoming an increasingly common disease that affects people of all ages and has no discernible link to specific risk factors. Parallel to the increase in cancer incidence, science has achieved incredible advances in the development of new antitumor drugs, as well as in treatment plan and other complementary therapeutic approaches. Although several treatment protocols have been established to reduce the harmful effects of chemotherapeutics on the human body, an ideal therapeutic system that kills exclusively neoplastic cells while keeping healthy tissues intact has not yet been introduced in the clinic. One field of nanotechnology aims to design advanced carriers and drug release systems that are as close to this ideal as feasible, so that they have a strong affinity for cancer cells and, if possible, specificity for certain types of cancer but do not impact healthy cells or become active just in the proximity of the malignant tissue.

The goal of this Special Issue of Pharmaceutics is to publish original research and review papers comprising the newest findings on various nanomaterials capable of efficiently delivering therapeutic agents to disease sites. We welcome scientists to share their expert comments and insights on all aspects of the synthesis, characterization, and in vitro or in vivo applications of such innovative  nanomaterials for the benefit of the fight against cancer.

Dr. Cristina Mariana Uritu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug release
  • drug delivery
  • targeted delivery system
  • nanoparticles
  • nanomaterials
  • tumor targeting
  • cancer therapy

Published Papers (1 paper)

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Article
CD163 Monoclonal Antibody Modified Polymer Prodrug Nanoparticles for Targeting Tumor-Associated Macrophages (TAMs) to Enhance Anti-Tumor Effects
by
Zun Yang
,
Haijiao Li
,
Wenrui Zhang
,
Mingzu Zhang
,
Jinlin He
,
Zepeng Yu
,
Xingwei Sun
and
Peihong Ni
Pharmaceutics 2023, 15(4), 1241; https://doi.org/10.3390/pharmaceutics15041241 - 14 Apr 2023
Viewed by 682
Abstract
Tumor-associated macrophages (TAMs)-based immunotherapy is a promising strategy. Since TAMs are mainly composed of M2-type macrophages, they have a promoting effect on tumor growth, invasion, and metastasis. M2-type macrophages contain a specific receptor CD163 on their surface, providing a prerequisite for active targeting [...] Read more.
Tumor-associated macrophages (TAMs)-based immunotherapy is a promising strategy. Since TAMs are mainly composed of M2-type macrophages, they have a promoting effect on tumor growth, invasion, and metastasis. M2-type macrophages contain a specific receptor CD163 on their surface, providing a prerequisite for active targeting to TAMs. In this study, we prepared CD163 monoclonal antibody modified doxorubicin-polymer prodrug nanoparticles (abbreviated as mAb-CD163-PDNPs) with pH responsiveness and targeted delivery. First, DOX was bonded with the aldehyde group of a copolymer by Schiff base reaction to form an amphiphilic polymer prodrug, which could self-assemble into nanoparticles in the aqueous solution. Then, mAb-CD163-PDNPs were generated through a “Click” reaction between the azide group on the surface of the prodrug nanoparticles and dibenzocyclocytyl-coupled CD163 monoclonal antibody (mAb-CD163-DBCO). The structure and assembly morphology of the prodrug and nanoparticles were characterized by 1H NMR, MALDI-TOF MS, FT-IR UV-vis spectroscopy, and dynamic light scattering (DLS). In vitro drug release behavior, cytotoxicity, and cell uptake were also investigated. The results show that the prodrug nanoparticles have regular morphology and stable structure, especially mAb-CD163-PDNPs, which can actively target TAMs at tumor sites, respond to the acidic environment in tumor cells, and release drugs. While depleting TAMs, mAb-CD163-PDNPs can actively enrich drugs at the tumor site and have a strong inhibitory effect on TAMs and tumor cells. The result of the in vivo test also shows a good therapeutic effect, with a tumor inhibition rate of 81%. This strategy of delivering anticancer drugs in TAMs provides a new way to develop targeted drugs for immunotherapy of malignant tumors. Full article
(This article belongs to the Special Issue Designing Nanomaterials for Drug Delivery and Cancer-Targeted Therapy)
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