Special Issue "Bioactive Peptides and Their Role in Drug Development"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 618

Special Issue Editors

Environmental Science Laboratory, School of Applied Sciences, KIIT Deemed to be University, Bhubaneswar 751024, India
Interests: protein chemistry; proteomics; natural products; ethnobotany; ethnomedicine; environmental remediation
1. 1H-TOXRUN One Health Toxicology Research Unit, Cooperativa de Ensino Superior Politécnicoe Universitário Grandra, Paredes, Portugal
2. LEPABE—Laboratory for Process Engineering, Environment, Biotechnology & Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal
Interests: biofilms; Candida; AMR; antifungal resistance; gene regulation; mechanism of action; bacteria, polymicrobial biofilm; alternative treatment; infection
Special Issues, Collections and Topics in MDPI journals
Department of Zoology, Utkal University, Bhubaneswar 751004, Odisha, India
Interests: natural products; ethnopharmacology; plant extracts; bioactivity; phytochemistry

Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in this Special Issue of Pharmaceutics titled “Bioactive Peptides and Their Role in Drug Development”. This Special Issue is dedicated to the publication of original research articles, reviews and short communications addressing all aspects of the discovery and characterization of bioactive peptides, their biological function and mechanism and their uses in the development of drugs, pharmaceuticals, and nutraceuticals.

Peptides are short polymers comprising 2–50 amino acid monomers. Bioactive peptides are considered as biomolecules, which are inherently buried inside proteins and become active upon cleavage or proteolysis. Many groups of bioactive peptides are found in microorganisms, plants, marine invertebrates etc., supporting these organisms in their survival and acting as defense molecules against pathogens and external insults. Naturally occurring bioactive peptides play a vital role in many regulatory functions and exhibit various types of bioactive properties, such as antimicrobial, antihypertensive, and antioxidant activities; anti-aggregation; ability to bind minerals; anti-obesity, antidiabetic and antiaging effects etc. The synthesis and degradation of proteins in various organisms gives rise to a complex pool of bioactive peptides having several functions. Additionally, many bioactive peptides are generated by recombinant synthesis and proteolytic digestion by several enzymes. The development of solid-phase peptide synthesis has provided us with excellent opportunities to tailor and develop highly efficient bioactive peptides.

Thus, this Special Issue aims to highlight recent advances in all aspects of state-of-the-art analytical techniques and methods for peptides, such as sample preparation, separation and detection as well as data processing, as well as the various applications of peptides. We particularly welcome manuscripts focusing on functional and structural aspects of interactions between peptides and other biological molecules, leading to the development of pharmaceutical drugs and nutraceuticals, as well as their contribution to other biologically relevant entities. We also welcome manuscripts describing the discovery of novel peptides having multiple bioactivities.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Novel peptides with multiple bioactive properties.
  2. Peptide–protein interactions leading to drug developments.
  3. Peptide–drug interactions outlying the mechanism of interaction.
  4. Peptides with chaperoning properties outlying the mechanism.
  5. Peptide engineering to develop more efficient bioactive peptides.

We look forward to receiving your contributions.

Dr. Alok Kumar Panda
Dr. Célia F. Rodrigues
Dr. Sujogya Kumar Panda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Preparation of Nanoemulsions with Low-Molecular-Weight Collagen Peptides from Sturgeon Fish Skin and Evaluation of Anti-Diabetic and Wound-Healing Effects in Mice
Pharmaceutics 2023, 15(9), 2304; https://doi.org/10.3390/pharmaceutics15092304 - 12 Sep 2023
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This study aims to isolate collagen peptides from waste sturgeon fish skin, and prepare nanoemulsions for studying their anti-diabetic and wound-healing effects in mice. Collagen peptides were extracted and purified by acetic acid with sonication, followed by two-stage hydrolysis with 0.1% pepsin and [...] Read more.
This study aims to isolate collagen peptides from waste sturgeon fish skin, and prepare nanoemulsions for studying their anti-diabetic and wound-healing effects in mice. Collagen peptides were extracted and purified by acetic acid with sonication, followed by two-stage hydrolysis with 0.1% pepsin and 5% flavourzyme, and ultrafiltration with 500 Da molecular weight (MW) cut-off dialysis membrane. Animal experiments were performed with collagen peptides obtained by pepsin hydrolysis (37 kDa) and pepsin plus flavourzyme hydrolysis (728 Da) as well as their nanoemulsions prepared at two different doses (100 and 300 mg/kg/day). The mean particle size of low-MW and low-dose nanoemulsion, low-MW and high-dose nanoemulsion, high-MW and low-dose nanoemulsion and high-MW and high-dose nanoemulsion was, respectively, 16.9, 15.3, 28.1 and 24.2 nm, the polydispersity index was 0.198, 0.215, 0.231 and 0.222 and zeta potential was −61.2, −63.0, −41.4 and −42.7 mV. These nanoemulsions were highly stable over a 90-day storage period (4 °C and 25 °C) and heating at 40–100 °C (0.5–2 h). Experiments in mice revealed that the low-MW and high-dose nanoemulsion was the most effective in decreasing fasting blood glucose (46.75%) and increasing wound-healing area (95.53%). Collectively, the sturgeon fish skin collagen peptide-based nanoemulsion is promising for development into a health food or wound-healing drug. Full article
(This article belongs to the Special Issue Bioactive Peptides and Their Role in Drug Development)
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