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Special Issue "Pharmaceutical Formulations with Antimicrobial Properties, 2nd Edition"

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A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 3944

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Special Issue Editors

Dr. Anca Niculina Cadinoiu

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Guest Editor

Department of Biomaterials, Faculty of Medical Dentistry, "Apollonia" University of Iasi, Pacurari Street, No. 11, 700511 Iasi, Romania
Interests: drug delivery; biomaterials; polymer nanoparticles; liposomes; hydrogels
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Prof. Dr. Marcel Popa

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“Cristofor Simionescu” Faculty of Chemical Engineering and Environment Protection, “Gheorghe Asachi” Technical University, 700050 Iasi, Romania
Interests: polysaccharide modification; bioactive polymers; biomaterials; hydrogels; interpenetrated networks; micro- and nanoparticles (spheres and capsules); hybrid and functionalized nanoparticles for drug targeting; drug delivery; polymer–drug conjugates
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Numerous studies on the systemic administration of antimicrobial drugs can be found in the literature. However, there are many challenges related to site-specific drug delivery, unwanted side effects and even potential toxicity. In order to address these, it is necessary to explore new approaches to the administration of active principles with antimicrobial properties. Therefore, in this Special Issue, we will focus on new delivery systems for antimicrobial applications, with a major emphasis on topical and targeted delivery. Examples of antimicrobial applications include wound healing; the prevention and treatment of periodontal diseases and tooth decay; and treatment of ear, skin, urinary tract, vaginal or respiratory infections. The systems used to release antimicrobial principles could take the form of gels, hydrogels, emulsions, micro- and nanoparticles (spheres, capsules, liposomes) or nanofibers.

Dr. Anca Niculina Cadinoiu
Prof. Dr. Marcel Popa
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

drug delivery systems
antimicrobial properties
topical delivery
targeted delivery
hydrogels
nanoparticles
liposomes
emulsions
nanofibers

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Pharmaceutical Formulations with Antimicrobial Properties in Pharmaceutics (14 articles)

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Research

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Open AccessArticle

Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles

and

Pharmaceutics 2023, 15(3), 809; https://doi.org/10.3390/pharmaceutics15030809 - 02 Mar 2023

Cited by 2 | Viewed by 911

Abstract

New hybrid materials based on Ag nanoparticles stabilized by a polyaminopropylalkoxysiloxane hyperbranched polymer matrix were prepared. The Ag nanoparticles were synthesized in 2-propanol by metal vapor synthesis (MVS) and incorporated into the polymer matrix using metal-containing organosol. MVS is based on the interaction of extremely reactive atomic metals formed by evaporation in high vacuum (10⁻⁴–10⁻⁵ Torr) with organic substances during their co-condensation on the cooled walls of a reaction vessel. Polyaminopropylsiloxanes with hyperbranched molecular architectures were obtained in the process of heterofunctional polycondensation of the corresponding AB₂-type monosodiumoxoorganodialkoxysilanes derived from the commercially available aminopropyltrialkoxysilanes. The nanocomposites were characterized using transmission (TEM) and scanning (SEM) electron microscopy, X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR). TEM images show that Ag nanoparticles stabilized in the polymer matrix have an average size of 5.3 nm. In the Ag-containing composite, the metal nanoparticles have a “core-shell” structure, in which the “core” and “shell” represent the M⁰ and M^δ+ states, respectively. Nanocomposites based on silver nanoparticles stabilized with amine-containing polyorganosiloxane polymers showed antimicrobial activity against Bacillus subtilis and Escherichia coli. Full article

(This article belongs to the Special Issue Pharmaceutical Formulations with Antimicrobial Properties, 2nd Edition)

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Open AccessArticle

In Vitro and In Vivo Characterisation of a Mucoadhesive Buccal Film Loaded with Doxycycline Hyclate for Topical Application in Periodontitis

Cristian Mircea Dudescu

Luciana-Mădălina Gherman

and

Pharmaceutics 2023, 15(2), 580; https://doi.org/10.3390/pharmaceutics15020580 - 08 Feb 2023

Cited by 1 | Viewed by 1215

Abstract

Mucoadhesive films loaded with doxycycline hyclate (Doxy Hyc), consisting of mixtures of hydroxypropylmethyl cellulose (HPMC) E3, K4 and polyacrylic acid (Carbopol 940), were prepared by casting method, aiming to design a formulation intended for application in the oral cavity. The obtained film formulations exhibited a Doxy Hyc content between 7.52 ± 0.42 and 7.83 ± 0.41%, which had adequate mechanical properties for application in the oral cavity and pH values in the tolerance range. The x-ray diffraction studies highlighted the amorphisation of Doxy Hyc in the preparation process and the antibiotic particles present on the surface of the films, identified in the TEM images, which ensured a burst release effect in the first 15 min of the in vitro dissolution studies, after which Doxy Hyc was released by diffusion, the data presenting a good correlation with the Peppas model, n < 0.5. The formulation F1, consisting of HPMC K4 combined with C940 in a ratio of 5:3, the most performing in vitro, was tested in vivo in experimentally-induced periodontitis and demonstrated its effectiveness in improving the clinical parameters and reducing the salivary levels of matrix metalloproteinase-8 (MMP-8). The prepared Doxy Hyc loaded mucoadhesive buccal film could be used as an adjuvant for the local treatment of periodontitis, ensuring prolonged release of the antibiotic after topical application. Full article

(This article belongs to the Special Issue Pharmaceutical Formulations with Antimicrobial Properties, 2nd Edition)

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Review

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Recent Progress and Trends in the Development of Electrospun and 3D Printed Polymeric-Based Materials to Overcome Antimicrobial Resistance (AMR)

Pablo C. Caracciolo

Gustavo A. Abraham

Ernesto S. Battaglia

and

Silvestre Bongiovanni Abel

Pharmaceutics 2023, 15(7), 1964; https://doi.org/10.3390/pharmaceutics15071964 - 16 Jul 2023

Cited by 1 | Viewed by 1156

Abstract

Antimicrobial resistance (AMR) developed by microorganisms is considered one of the most critical public health issues worldwide. This problem is affecting the lives of millions of people and needs to be addressed promptly. Mainly, antibiotics are the substances that contribute to AMR in various strains of bacteria and other microorganisms, leading to infectious diseases that cannot be effectively treated. To avoid the use of antibiotics and similar drugs, several approaches have gained attention in the fields of materials science and engineering as well as pharmaceutics over the past five years. Our focus lies on the design and manufacture of polymeric-based materials capable of incorporating antimicrobial agents excluding the aforementioned substances. In this sense, two of the emerging techniques for materials fabrication, namely, electrospinning and 3D printing, have gained significant attraction. In this article, we provide a summary of the most important findings that contribute to the development of antimicrobial systems using these technologies to incorporate various types of nanomaterials, organic molecules, or natural compounds with the required property. Furthermore, we discuss and consider the challenges that lie ahead in this research field for the coming years. Full article

(This article belongs to the Special Issue Pharmaceutical Formulations with Antimicrobial Properties, 2nd Edition)

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