Controlled-Release Systems for Ophthalmic Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 916

Special Issue Editors


E-Mail Website
Guest Editor
Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA
Interests: ophthalmic; long-acting injectables; intrauterine systems; IVIVCs development; gold nanoparticles; complex drug products; formulation sciences

E-Mail Website
Guest Editor
Thermo Fisher Scientific, 5900 MLK Jr Hwy, Greenville, NC 27834, USA
Interests: ophthalmic delivery: lipid nano particles, nano emulsions, inserts, films, in situ gels; glaucoma; keratitis; small molecules; biologics; oral delivery; drug product development
Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA
Interests: intravitreal formulation; long-acting injectables; PBBM modeling; biorelevant dissolution

Special Issue Information

Dear Colleagues,

Ophthalmic dosage forms or ocular drug delivery systems face tremendous challenges ranging from drug delivery strategies, formulation, manufacturing, quality control and bioequivalence evaluation due to the complex anatomy of human eyes. In addition, most of the ophthalmic route of administration is for local drug delivery; therefore, the commonly used pharmacokinetic approach is not sufficient to evaluate the absorption of these formulations. Over the past several decades, efforts have been made to improve the bioavailability of the ophthalmic formulations through controlled or sustained drug delivery strategies such as implants (intraocular or intravitreal), long-acting injectable suspensions, and ophthalmic gels. This Special Issue will focus on the controlled or sustained drug delivery of both small and large molecules for ophthalmic application. Both comprehensive reviews and research manuscripts in this area are welcome.

We look forward to receiving your contributions.

Dr. Quanying Bao
Dr. Narendar Dudhipala
Dr. Laibin Luo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • controlled release
  • ophthalmic
  • drug delivery
  • intravitreal
  • implants
  • gels

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

13 pages, 914 KiB  
Review
Ranibizumab Port Delivery System in Neovascular Age-Related Macular Degeneration: Where Do We Stand? Overview of Pharmacokinetics, Clinical Results, and Future Directions
by Matteo Mario Carlà, Maria Cristina Savastano, Francesco Boselli, Federico Giannuzzi and Stanislao Rizzo
Pharmaceutics 2024, 16(3), 314; https://doi.org/10.3390/pharmaceutics16030314 - 23 Feb 2024
Viewed by 603
Abstract
The ranibizumab (RBZ) port delivery system (PDS) is a device designed to continuously deliver RBZ in the vitreous chamber for the treatment of neovascular age-related macular degeneration (nAMD). It is implanted during a surgical procedure and can provide sustained release of the medication [...] Read more.
The ranibizumab (RBZ) port delivery system (PDS) is a device designed to continuously deliver RBZ in the vitreous chamber for the treatment of neovascular age-related macular degeneration (nAMD). It is implanted during a surgical procedure and can provide sustained release of the medication for several months. This review, updated to January 2024, focuses on past clinical studies as well as current and forthcoming trials looking into a PDS with RBZ. In the phase 2 LADDER trial, the mean time to first refill of a PDS with RBZ 100 mg/mL was 15.8 months, with the pharmacokinetic (PK) profile showing a sustained concentration of RBZ in the blood and aqueous humor. More recently, a PDS with RBZ (100 mg/mL) refilled every 24 weeks was shown to be non-inferior to a monthly intravitreal injection (IVI) with RBZ (0.5 mg) over 40 and 92 weeks in the phase 3 ARCHWAY trial. The refill every 24 weeks allowed for a RBZ vitreous exposure within the concentration range of monthly intravitreal injections (IVIs), and the expected half-life (106 days) was comparable with the in vitro results. Nonetheless, vitreous hemorrhage and endophthalmitis were more common side effects in PDS patients. In conclusion, a PDS continuously delivering RBZ has a clinical effectiveness level comparable with IVI treatment. However, a greater frequency of unfavorable occurrences highlights the need for procedure optimization for a wider adoption. Ongoing trials and possible future approaches need to be addressed. Full article
(This article belongs to the Special Issue Controlled-Release Systems for Ophthalmic Applications)
Show Figures

Figure 1

Back to TopTop