Special Issue "Drug Metabolism/Transport and Pharmacokinetics in Biological Drugs"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (10 September 2023) | Viewed by 150

Special Issue Editors

Dr. Mila Lovrić
E-Mail Website
Guest Editor
School of Medicine, University of Zagreb, Zagreb, Croatia
Interests: analytical toxicology; clinical toxicology; therapeutic drug monitoring
Dr. Miranda Sertić
E-Mail Website
Guest Editor
Department of Pharmaceutical Analysis, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Interests: pharmaceutical analysis; therapeutic drug monitoring; LC-MS; capillary electrohoresis
Dr. Ana Kozmar
E-Mail Website
Guest Editor
KBC Osijek, Osijek, Croatia
Interests: systemic lupus erythematosus; autoantibodies; Sjogren's syndrome; diabetic retinopathy

Special Issue Information

Dear Colleagues,

Biological drugs often represent the forefront of biomedical research as a diverse group of medicines which includes vaccines, growth factors, immune modulators, and monoclonal antibodies, as well as products derived from human blood and plasma. What distinguishes biologicals from most drugs that are chemically synthesized is their complex heterogeneous structure with high molecular weight.

Biological drugs have been in clinical use for few decades and their complexity has advanced considerably over the years, particularly with the introduction of conjugated and modified proteins; therefore, there is a need to investigate and better characterize their metabolism.

Compared to small-molecule drugs, biologicals have unique characteristics in absorption, distribution, metabolism, and elimination, leading to significant differences in their development.

The pharmacokinetic properties of these drugs, especially monoclonal antibodies, are significantly different from chemical drugs and are affected by many factors such as their possible immunogenicity or target-mediated clearance (target-mediated drug disposition (TMDD)).

In this Special Issue, original research articles, reviews, and emerging ideas are welcome. The research areas of interest include the current knowledge of metabolism and the transport and pharmacokinetics of biological drugs that would improve the understanding of efficient drug delivery and therapy.

We look forward to receiving your contributions.

Dr. Mila Lovrić
Dr. Miranda Sertić
Dr. Ana Kozmar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biological drugs
  • biologicals
  • immune modulators
  • monoclonal antibodies
  • absorption
  • distribution
  • metabolism
  • elimination, drug transport
  • pharmacokinetics
  • drug delivery

Published Papers

There is no accepted submissions to this special issue at this moment.
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