Special Issue "Drug Metabolism/Transport and Pharmacokinetics in Biological Drugs"
Deadline for manuscript submissions: closed (10 September 2023) | Viewed by 150
Interests: analytical toxicology; clinical toxicology; therapeutic drug monitoring
Interests: pharmaceutical analysis; therapeutic drug monitoring; LC-MS; capillary electrohoresis
Biological drugs often represent the forefront of biomedical research as a diverse group of medicines which includes vaccines, growth factors, immune modulators, and monoclonal antibodies, as well as products derived from human blood and plasma. What distinguishes biologicals from most drugs that are chemically synthesized is their complex heterogeneous structure with high molecular weight.
Biological drugs have been in clinical use for few decades and their complexity has advanced considerably over the years, particularly with the introduction of conjugated and modified proteins; therefore, there is a need to investigate and better characterize their metabolism.
Compared to small-molecule drugs, biologicals have unique characteristics in absorption, distribution, metabolism, and elimination, leading to significant differences in their development.
The pharmacokinetic properties of these drugs, especially monoclonal antibodies, are significantly different from chemical drugs and are affected by many factors such as their possible immunogenicity or target-mediated clearance (target-mediated drug disposition (TMDD)).
In this Special Issue, original research articles, reviews, and emerging ideas are welcome. The research areas of interest include the current knowledge of metabolism and the transport and pharmacokinetics of biological drugs that would improve the understanding of efficient drug delivery and therapy.
We look forward to receiving your contributions.
Dr. Mila Lovrić
Dr. Miranda Sertić
Dr. Ana Kozmar
Manuscript Submission Information
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- biological drugs
- immune modulators
- monoclonal antibodies
- elimination, drug transport
- drug delivery