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► Journal BrowserSpecial Issue "Formulation of Poorly Water-Soluble Drugs"
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 31 December 2023 | Viewed by 734
Special Issue Editors
Interests: poorly water-soluble drugs; crystalline/amorphous drugs; amorphous solid dispersions; nanocrystals; novel drug-delivery systems
Interests: lipid nanoparticles; zwitterionic micelles; drug conjugates; nanosuspensions
Interests: targeted drug delivery; metabolsim modulation; membrane transporters; novel drug-delivery systems
Special Issue Information
Dear Colleagues,
In recent years, the emergence of poorly water-soluble drug candidates in the drug development pipeline has been a challenging issue for the pharmaceutical industry. Increasing the bioavailability of these drugs via the improvement of solubility/dissolution has become a major concern in the efforts to develop a reasonable dosing regimen for patients. Many delivery systems, such as cocrystals, nanocrystals, nanoparticles, inclusion complex, amorphous solid dispersions, and lipid-based formulations have been developed to overcome these problems. The use of novel methods not only increases the solubility and permeability of the poorly bioavailable drugs but also improves their stability and targeting efficacy. Moreover, in order to select the best approach some critical considerations must be taken into account, for example the physicochemical properties of the drug, the possibility to scale-up the production process, the toxicological considerations of the use of adjuvant, and the development of a more patient-friendly dosage form.
This Special Issue aims to collect groundbreaking studies and valuable reviews on the formulation of poorly water-soluble drugs.
Prof. Dr. Qiang Fu
Dr. Xiangfei Han
Dr. Longfa Kou
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- poorly water-soluble drugs
- solubility
- dissolution enhancement
- oral bioavailability
- physico-chemical properties
- drug delivery
- formulation design
- cocrystals
- nanocrystals
- inclusion complex
- amorphous solid dispersions
- nanoparticles
- liposome
- lipid-based formulations.
