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Pharmaceutics
Special Issues
Advanced Nanotechnology in Drug Delivery
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Advanced Nanotechnology in Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 4356

Special Issue Editor

Prof. Dr. Pierre P.D. Kondiah

E-Mail Website
Guest Editor
1. WADDP Research Unit, Department of Pharmacy and Pharmacology, and Wits Business School, Wits University, Johannesburg 2193, South Africa
2. Pearson College London Alumni, London, UK
Interests: biomedicine; nanotechnology in drug delivery; peptide chemistry; nanomedicine and biochemistry; stimuli-responsive drug delivery

Special Issue Information

Dear Colleagues, 

This Special Issue will entail advanced nanotechnological research, in relation to drug delivery technologies. Nano-systems investigated, will comprise of physical or chemical crosslinking of natural or synthetic polymers in drug delivery systems, with significant capacity to retain its loaded drug or biomolecule, without dissolving immediately, due to the presence of hydrophilic or amphiphilic molecular chains. Nano-systems which corresponds with the fluid-like transport characteristics of physiologically active compounds that are significantly lower than its pore size, including stimuli-responsive drug delivery and polymeric systems, have great potential for application in controlling the delivery. This is due to their size, tuneability and biocompatibility. The issue will also look at how drug delivery and nanotechnologies, have progressed with new equipment for synthesis and analysis, to date, allowing greater insight into imaging, physical characterizations, and its chemical analysis.

Prof. Dr. Pierre P.D. Kondiah
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nano-systems
  • drug delivery
  • polymers
  • nanogels
  • biocompatibility
  • stimuli-responsive drug delivery
  • chemical analysis

Published Papers (2 papers)

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Research

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20 pages, 5991 KiB  
Article
Ultrasonically Fabricated Beta-Carotene Nanoemulsion: Optimization, Characterization and Evaluation of Combinatorial Effect with Quercetin on Streptozotocin-Induced Diabetic Rat Model
by Manohar Mahadev, Akhilesh Dubey and Amitha Shetty
Pharmaceutics 2023, 15(2), 574; https://doi.org/10.3390/pharmaceutics15020574 - 08 Feb 2023
Cited by 1 | Viewed by 1787
Abstract
Diabetes mellitus (D.M.) is a metabolic disease that has affected over 500 million people globally. Bioactive compounds such as β-carotene and Quercetin have gained research interest for their potential antidiabetic properties, and bioactives have reported superior combinatorial effects in several ailments, including D.M. [...] Read more.
Diabetes mellitus (D.M.) is a metabolic disease that has affected over 500 million people globally. Bioactive compounds such as β-carotene and Quercetin have gained research interest for their potential antidiabetic properties, and bioactives have reported superior combinatorial effects in several ailments, including D.M. However, poor oral bioavailability has limited their potential application. Thus, the present study was focused on developing ultrasonically fabricated β-Carotene nanoemulsion (βC-NE) by employing capmul as the oil phase, Gelucire 44/14 as surfactant and Acconon MCM C8 as co-surfactant. The 3 factor- 3 level Box-Behnken design (BBD) was applied to optimise the βC-NE and study the impact of selected independent variables such as % Smix (5 to 9%), amplitude (20–30%) and sonication time (2.5–7.5 min) on responses including globule size (G.S.), poly dispersibility Index (PDI) and entrapment efficiency (E.E.). Further, the combinatorial effect of βC-NE with Quercetin Nanoemulsion (QU-NE) in the streptozotocin-induced diabetic rat model was evaluated. The results exhibited that 7% Smix at 25% amplitude for 5 min produced βC-NE with a droplet size of 153.1 ± 12.25 nm, 0.200 ± 0.04 PDI, and 73.25 ± 3.25% E.E. The βC-NE showed superior in-vivo bioavailability by 5.38 folds. The βC-NE, combined with QU-NE, exhibited potential therapeutic benefits in controlling body weight, blood sugar level, lipid levels, and tissue damage markers. Additionally, the pancreatic cells and hepatic cells were well protected. These results demonstrate the potential benefits of βC-NE and QU-NE in combination and recommend them as a substitute strategy for diabetes. Full article
(This article belongs to the Special Issue Advanced Nanotechnology in Drug Delivery)
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Review

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31 pages, 2641 KiB  
Review
Biomedicine Innovations and Its Nanohydrogel Classifications
by Sifiso S. Makhathini, Sipho Mdanda, Pariksha J. Kondiah, Moosa E. Kharodia, Karl Rumbold, Imhotep Alagidede, Yashwant Pathak, Zain Bulbulia, Thankhoe A. Rants’o and Pierre P. D. Kondiah
Pharmaceutics 2022, 14(12), 2839; https://doi.org/10.3390/pharmaceutics14122839 - 18 Dec 2022
Cited by 7 | Viewed by 1929
Abstract
As one of the most cutting-edge and promising polymer crosslinked network nanoparticle systems. Polymer nano-sized hydrogels (nanogels) have been a hot topic in the biomedical field over the last few decades. Due to their unique characteristics, which include their relatively high drug encapsulation [...] Read more.
As one of the most cutting-edge and promising polymer crosslinked network nanoparticle systems. Polymer nano-sized hydrogels (nanogels) have been a hot topic in the biomedical field over the last few decades. Due to their unique characteristics, which include their relatively high drug encapsulation efficiency, ease of preparation, high tunability, low toxicity, high stability in serum and responsive behavior to a range of stimuli to facilitate drug release. Nanogels are thought to be the next generation of drug delivery systems that can completely change the way that drug delivery systems have an impact on patients’ lives. Nanogels have demonstrated significant potential in a variety of fields, including chemotherapy, diagnosis, organ targeting, and delivery of bioactive molecules of different dimensions. However, the lack of substantial clinical data from nanogels becomes one of the major barriers to translating the nanogel concept into a practical therapeutic application for many disease conditions. In addition, nanogel safety profiles have been the major concern that hinders it advancement to the clinical trial phase. This review aims to emphasize the unique properties of nanogels as delivery systems for a variety of bioactive molecules over other nano-delivery systems. Also, this review attempts to give insight into the recent progress in nanogels as a carrier in the field of nanomedicine to overcome complex biological barriers. Relevant scientific data and clinical rationale for the development and the potential use of nanogel as a carrier for targeted therapeutic interventions are discussed. Finally, the concluding points of this review highlight the importance of understanding the long-term toxicity profile of nanogel within the biological system to fully understand their biocompatibility. Full article
(This article belongs to the Special Issue Advanced Nanotechnology in Drug Delivery)
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