Radiopharmaceuticals for Relapsed or Refractory Ovarian Cancers

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Radiopharmaceutical Sciences".

Deadline for manuscript submissions: closed (25 June 2021)

Special Issue Editor


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Guest Editor
National Cancer Institute, Division of Cancer Treatment and Diagnosis, Cancer Therapy Evaluation Program, Investigational Drug Branch, Medical Officer and Coordinator, Investigational Therapeutics & Radiation, Rockville, MD, USA
Interests: radiopharmaceuticals; radiotherapy; gynecological cancer

Special Issue Information

Dear Colleagues,

An overarching aspect for the radiopharmaceutical drug development effort is patient and provider education through use of academic white papers on key topics. The Journal Pharmaceuticals has offered us the opportunity to write academic white papers for a Special Issue on “Radiopharmaceuticals for Relapsed or Refractory Ovarian Cancers.” The focus of this effort is to introduce and to describe the United States National Cancer Institutes and the academic or pharmaceutical collaborator development of these agents. Topics might range from radiopharmaceutical combination with early-phase investigational agents that test tolerability and early signs of efficacy or social aspects of this type of research, such as financial toxicity.

Some of the initial topics discussed by the NCI are found at this link to serve as a topic guide:

https://ctep.cancer.gov/investigatorResources/radiopharmaceutical_development_initiative.htm

Please email me at charles.kunos@nih.gov to discuss your planned topic so that there is not significant overlap in contributed material.

Charles A Kunos, MD PhD
Guest Editor

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Keywords

  • radiopharmaceuticals
  • radiotherapy
  • ovarian cancer
  • stereotactic
  • financial toxicity

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Published Papers (1 paper)

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9 pages, 201 KiB  
Opinion
Financial Toxicity Encountered in Therapeutic Radiopharmaceutical Clinical Development for Ovarian Cancer
by Charles A. Kunos and Rita Abdallah
Pharmaceuticals 2020, 13(8), 181; https://doi.org/10.3390/ph13080181 - 5 Aug 2020
Cited by 2 | Viewed by 2886
Abstract
Financial toxicity or the debt a cancer survivor incurs from the costs of their medical cancer care is an understudied aspect in the clinical development of experimental therapeutic agents. The United States National Cancer Institute (NCI) Cancer Therapy Evaluation Program studies experimental therapeutic [...] Read more.
Financial toxicity or the debt a cancer survivor incurs from the costs of their medical cancer care is an understudied aspect in the clinical development of experimental therapeutic agents. The United States National Cancer Institute (NCI) Cancer Therapy Evaluation Program studies experimental therapeutic agents like radiopharmaceuticals in both early and late phase trials, which provide opportunities to comprehend more clearly the possible sources of financial toxicity incurred by cancer survivors. We reviewed the academic scholarship describing fiscal and social costs involved in the development of therapeutic radiopharmaceuticals. Because many ovarian cancer survivors outlive their disease through initial and, perhaps, multiple treatment courses, these women and their treatments provide context for our discussion on financial toxicity. 16 (27%) of 60 articles discuss financial toxicity incurred by women with ovarian cancer; none described financial toxicity associated with regulatory agency-approved or experimental therapeutic radiopharmaceuticals. Fiscal costs of radiopharmaceutical dose and schedule and social costs of individual productivity loss or asset expenditure arose as primary financial toxicities. The development of radiopharmaceuticals for women with ovarian cancer remains a high priority for the NCI Cancer Therapy Evaluation Program. Weighing radiopharmaceutical clinical benefit against measures of financial toxicity is challenging and warrants further study in prospective radiopharmaceutical clinical trials. Full article
(This article belongs to the Special Issue Radiopharmaceuticals for Relapsed or Refractory Ovarian Cancers)
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