Recent Advances in the Pharmacotherapy of Peripheral Nervous System Tumors
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: closed (3 April 2023) | Viewed by 3759
Special Issue Editors
Interests: PNS tumors; intraoperative fluorescence; vascular malformations
Special Issues, Collections and Topics in MDPI journals
Interests: familial tumor syndromes; immunotherapy; nervous system tumors
Interests: neurocutaneous diseases; genetic syndromes; Nervous System tumors
Special Issue Information
Dear Colleagues,
The management of peripheral nervous system (PNS) tumors has traditionally been reserved for surgical treatment. However, not all PNS tumors are suitable for surgery due to the possible morbidity or the limited role in the case of multiple tumors. This is particularly true for neurocutaneous disease-related lesions, such as plexiform neurofibromas or malignant peripheral nerve sheath tumors (MPNSTs), in particular considering the significant limitations to conventional therapeutic options in general for such tumors. During the last years, the peculiar clinical behavior of such tumors, along with the risk of developing multiple tumors over time, has shifted the focus to the need for prevention and for symptomatic treatment in recurrent or inoperable forms. Recently, the availability of oral drugs acting as MEK inhibitors for patients with plexiform neurofibromas and neurofibromatosis type 1 has substantiated a significant advance in patients’ care. Novel drugs are also available for MPNSTs. However, no significant progress has been made for patients with either neurofibromatosis type 2 or schwannomatosis, despite the availability of anti-angiogenetic drugs for vestibular schwannomas in NF2. Despite these premises, the need for more tumor-directed therapies with tolerable short- and long-term toxicities is needed, considering the complexity of the signaling pathways involved. The journal Pharmaceuticals invites both reviews and original articles shedding light on the challenges related to pharmacological management of all types of PNS tumors, both sporadic and occurring in familial tumor syndromes.The topics of this Special Issue include, but are not limited to: ongoing and concluded clinical trials, drug repositioning, optimization of side effects, molecular pathways and new possible targets, pharmaceuticals applications, and pharmacogenomic and drug responses.
Dr. Ignazio Gaspare Vetrano
Dr. Marica Eoli
Dr. Veronica Saletti
Guest Editors
Manuscript Submission Information
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Keywords
- neurofibromatosis
- MEK inhibition
- MPNST
- NF1
- NF2
- RAShopaties
- plexiform neurofibromas
- schwannomatosis
- selumetinib
