Pharmacological Therapeutic Strategies and Drug Delivery for Craniofacial District

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 5251

Special Issue Editor


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Guest Editor
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania, Luigi Vanvitelli, 80138 Naples, Italy
Interests: temporomandibular disorders; TED; temporomandibular joint; orofacial pain; dentistry; telemedicine; tele dentistry; implant; prosthesis; oral surgery
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Special Issue Information

Dear Colleagues,

This thematic issue aims to provide an update regarding new advances and knowledge in drug delivery and pharmacological therapeutic strategies for oral applications, including in vivo and in vitro studies. The topic includes different biomedical sectors and involves pathologies associated with pain and dysfunction in the orofacial district, providing a global overview of oral dentistry from innovative biomedical techniques to the molecular aspects of oral and periodontal disease pathogenesis. Updates in biomedical technologies to improve the prevention and treatment of oral health conditions, focusing on drug delivery and biotechnological applications of active compounds in the cranio-maxillofacial district, are of interest.

Dr. Giuseppe Minervini
Guest Editor

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Keywords

  • craniofacial district
  • natural products
  • drug delivery
  • TMD
  • oral surgery
  • oral cavity
  • temporomandibular disorder
  • oral pathology

Published Papers (2 papers)

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17 pages, 2172 KiB  
Systematic Review
The Benefits of Probiotics on Oral Health: Systematic Review of the Literature
by Francesco Inchingolo, Angelo Michele Inchingolo, Giuseppina Malcangi, Nicole De Leonardis, Roberta Sardano, Carmela Pezzolla, Elisabetta de Ruvo, Daniela Di Venere, Andrea Palermo, Alessio Danilo Inchingolo, Alberto Corriero and Gianna Dipalma
Pharmaceuticals 2023, 16(9), 1313; https://doi.org/10.3390/ph16091313 - 16 Sep 2023
Cited by 7 | Viewed by 2631
Abstract
Aim: Probiotic microorganisms, commonly used to bolster gut health, might also have benefits for dental health, according to certain studies. Probiotics (PBs) are associated with reducing cariogenic pathogens and protecting against periodontal diseases, although the exact way they function in the mouth [...] Read more.
Aim: Probiotic microorganisms, commonly used to bolster gut health, might also have benefits for dental health, according to certain studies. Probiotics (PBs) are associated with reducing cariogenic pathogens and protecting against periodontal diseases, although the exact way they function in the mouth is not fully clear. Our study aimed to explore the use of PBs to improve oral health, focusing on issues such as cavities, gum disease, bad breath, mucositis, and periimplantitis. Materials and Methods: We utilized the Boolean keywords “Probiotics” AND “Oral health” to search the databases of PubMed, Scopus, and Web of Science. The search was restricted to English-language papers published from 1 January 2019 to 13 April 2023. Results: A total of 3460 articles were found through our computerized search. After removing duplicates, reviewing the papers, and determining their relevance, 12 were selected for inclusion. Conclusions: Assessing how bacteria in food or dietary supplements might alter the stable oral microbiota is a complex task. Although probiotic microorganisms have been found to have proven therapeutic benefits, their application in dental health is not yet solidly backed by evidence. Further research is necessary to thoroughly understand the long-term effects of probiotic bacteria on the oral environment, including their ability to colonize and form biofilms. Full article
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13 pages, 914 KiB  
Systematic Review
Probiotics in the Treatment of Radiotherapy-Induced Oral Mucositis: Systematic Review with Meta-Analysis
by Giuseppe Minervini, Rocco Franco, Maria Maddalena Marrapodi, Luca Fiorillo, Almir Badnjević, Gabriele Cervino and Marco Cicciù
Pharmaceuticals 2023, 16(5), 654; https://doi.org/10.3390/ph16050654 - 27 Apr 2023
Cited by 4 | Viewed by 2118
Abstract
The inflammatory injury of the mucous membranes lining the digestive tract, from the mouth to the anus, is called mucositis. One of the intriguing and compelling new therapeutic modalities that has emerged in recent decades due to advances in our understanding of this [...] Read more.
The inflammatory injury of the mucous membranes lining the digestive tract, from the mouth to the anus, is called mucositis. One of the intriguing and compelling new therapeutic modalities that has emerged in recent decades due to advances in our understanding of this condition’s pathophysiology is probiotics. The purpose of this meta-analysis is to evaluate the efficiency of probiotics in the treatment of chemotherapy-induced mucositis for head and neck malignancies; a literature search was performed on PubMed, Lilacs, and Web of Science, and articles published from 2000 to 31 January 2023 were considered, according to the keywords entered. The term “Probiotics” was combined with “oral mucositis” using the Boolean connector AND; at the end of the research, 189 studies were identified from the search on the three engines. Only three were used to draw up the present systematic study and metanalysis; this meta-analysis showed that the treatment of mucositis with probiotics is an effective method, and the analysis of the results of these studies showed that the use of probiotics promoted a decrease in the severity of mucositis symptoms. Full article
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