Special Issue "The Pharmacology of Lysosome"
Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 4260
Interests: autophagy; molecular pharmacology; drug screening; lysosome biology
Interests: autophagy; mitophagy; lysosome; membrane trafficking; pharmacology
Interests: autophagy; lysosomal biogenesis; mitochondrial dynamics; ER homeostasis; cell death
Autophagy is a well-known lysosome-dependent pathway for protein degradation. Chemicals targeting autophagy–lysosome processes represent an efficient therapy strategy for various diseases. Lysosomes are major organelles that contain high levels of hydrolytic enzymes needed to integrate and digest materials compartmentalized by endocytosis, phagocytosis, or autophagy which serve as a cellular recycling center. The disturbance of lysosome function leads to defective vesicle trafficking, impaired autophagy, and various diseases (such as neurodegeneration, lysosomal storage disorders, and cancer) by interrupting ionic exchange and accumulating toxic materials (such as amyloid beta inside lysosomes). Thus, autophagy- and lysosome-modulating drugs may ameliorate such cell abnormalities.
Treatment with pharmacological agents targeting lysosome and autophagy pathway is becoming a promising strategy for cancer and neurodegenerative disorders therapy. A demonstration of how these drugs regulate autophagy–lysosome pathways, such as autophagosome–lysosome fusion, lysosomal degradation function, lysophagy, lysosome biogenesis, and lysosomal cell death, is urgently needed. In this Special Issue, any studies on the pharmacology of lysosomes regulated by drugs for disease therapy are welcome.
Dr. Min Li
Dr. Du Feng
Dr. Shaogui Wang
Manuscript Submission Information
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- cell death
- lysosome dysfunction
- drug–lysosome interaction
- lysosome enzyme
- lysosomal membrane
- drug discovery