Challenges and Opportunities in Developing Therapeutic Nucleic Acid Cargo and Delivery
Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 7548
Interests: nanomedicine; nucleic acid therapeutics; RNA; gene therapy; inflammation; bone and joint; cartilage; degenerative diseases; aging
Special Issues, Collections and Topics in MDPI journals
Interests: chemical engineering; organic synthesis; polymers; hydrogel; molecular modeling; tissue engineering
Interests: bioengineering; chemical priming; nonviral gene delivery; stem cells
Nucleic acid therapeutics is an emerging and exciting research field. Nothing illustrates its power better than mRNA vaccines against coronavirus, which have saved countless lives during the COVID-19 pandemic. The rapid development and production of mRNA vaccines is based on research in the nucleic acid therapeutics research field for many years prior to its success. More research and data are needed to sustain and expand the success of nucleic acid therapeutics. The main purpose of this Special Issue is to encourage the submission and publication of rigorous research and important findings in the nucleic acid therapeutic area. Recent advances in the field are based on cutting-edge molecular research, including gene therapy, gene silencing, and gene editing. Furthermore, chemical, physical, and biological modification of the nucleic acid cargo may improve stability, weaken immunogenicity, and reduce toxicity. Tissue and cellular delivery of nucleic acid therapeutics is the key since nucleic acid mainly functions within the cell, some of which within the nucleus. Our body presents many barriers to drug delivery, such as dense connective tissues, solid tumors with high interstitial fluid pressure, and the blood–brain barrier. A technology to overcome the delivery challenges of nucleic acid therapeutics is essential. Finally, targeted delivery and sustained release of nucleic acid therapeutics will not only improve drug efficacy but also achieve precision medicine.
The journal Pharmaceuticals invites both reviews and original articles shedding light on the challenges and opportunities of developing nucleic acid therapeutics, including both cargo and delivery. Related disciplines including cell and molecular biology, pharmacology and pharmaceutics, chemical and bioengineering, and translational and clinical sciences are welcome. Topics include but are not restricted to DNA and RNA drugs; gene therapy; gene editing; messenger RNA and noncoding RNA; RNAi, including microRNA and siRNA; long noncoding RNA and circular RNA; oligonucleotides, including anti-sense oligos (ASO), chemical, physical, and biological modification of nucleic acid cargo; delivery vehicles, including virus (AAV), lipid nanoparticles (LNP), polymers, proteins and peptides, and small molecules; delivery routes, including local and systemic; technologies to improve targeting, drug release, and modulation of gene expression; CMC and drug synthesis and formulation; novel disease applications; and potential side effects. The collection of manuscripts will be published as a Special Issue of the journal.
Prof. Dr. Qian Chen
Dr. Zhen Qiao
Dr. Andrew Hamann
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- nucleic acid therapeutics
- gene therapy
- gene editing
- mRNA vaccine
- nonviral gene delivery
- nucleic acid synthesis and delivery