Special Issue "Drug Delivery Systems for Local Anesthetics"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 716

Special Issue Editors

Department of Biosciences, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba 13083-970, SP, Brazil
Interests: topical anesthesia; oral cavity; oral mucosa; dental anesthesia; drug delivery; mucoadhesive system; dentistry
Special Issues, Collections and Topics in MDPI journals
Dr. Camila Batista Da Silva
E-Mail Website
Guest Editor
Department of Biosciences-Pharmacology, Anesthesiology & Therapeutics Area, Piracicaba Dental School, University of Campinas, Av. Limeira, nº 901, Bairro Areião, Piracicaba 13414-903, SP, Brazil
Interests: dentistry; local anesthetic; medical emergency; anxiety

Special Issue Information

Dear Colleagues,

Local anesthetics (LAs) are among the most useful drugs in anesthesiology practice and pain management, as they cause a temporary loss of pain by inhibiting the transmission of nerve impulses. Thus, they have been widely used in clinical practice. However, the applications of anesthetics are greatly limited due to their neurotoxicity and short half-lives. To overcome these barriers, numerous drug delivery systems (DDSs) have been designed to encapsulate local anesthetic agents so that large doses can be released slowly and provide analgesia over a prolonged period. Formulation approaches to systemically deliver LA include the encapsulation of liposomes, the complexation of cyclodextrins, and associations with biopolymers and other carrier systems. This Special Issue, entitled “Drug Delivery Systems for Local Anesthetics”, considers drug delivery formulations of local anesthetics designed to prolong the anesthetic effect and decrease toxicity.

We invite authors to submit original research articles or review articles outlining innovations pertaining to formulations and techniques for drug delivery of topical and injectable local anesthetics.

Prof. Dr. Michelle Franz-Montan
Dr. Camila Batista Da Silva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • local anesthetics
  • drug delivery system
  • liposomes
  • biopolymers
  • cyclodextrins
  • polymers
  • micro- and nanoparticles
  • topical formulations

Published Papers (1 paper)

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12 pages, 1944 KiB  
Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine
Pharmaceuticals 2023, 16(10), 1398; https://doi.org/10.3390/ph16101398 - 02 Oct 2023
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The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body. A possible way to increase the selectivity of the action [...] Read more.
The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body. A possible way to increase the selectivity of the action of drugs is to use the photopharmacology approach. Previously, we described the light-controlled local anesthetic ethercaine, the biological effect of which can be controlled using light, thereby increasing its selectivity of action. An important limitation of ethercaine was its low solubility in water, limiting the potential of this compound. In this work, we developed a dosage form of ethercaine, which allowed us to increase its solubility from 0.6% to 2% or more. The resulting 1% solution of ethercaine hydrochloride in 4% Kolliphor ELP had high biological activity on the surface anesthesia model, while demonstrating low acute toxicity in mice with intravenous administration (4–5 times less than that of lidocaine). Full article
(This article belongs to the Special Issue Drug Delivery Systems for Local Anesthetics)
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