Special Issue "Mass Spectrometry-Based Lipidomics in Drugs Discovery"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 227

Special Issue Editors

Prof. Dr. Hua Tian
E-Mail Website
Guest Editor
Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA
Interests: mass spectrometry; pharmacology
Department of Chemistry, Columbia University, New York, NY, USA
Interests: mass spectometry; imaging

Special Issue Information

Dear Colleagues,

Several human diseases, such as obesity, cardiovascular disease, cancer, and neurodegeneration, involve changes in lipids and lipid metabolic pathways. Alterations in the expression of different lipid molecules have been used to specify the functionality of various metabolic pathways in disease. In addition, the discoordination of lipids affects the upstream proteomic regulation and interaction. Therefore, many drugs that directly or indirectly affect lipid metabolic pathways can be developed. This information can be employed to identify druggable target enzymes to control the pathway of interest.

Mass spectrometry (MS)-based lipid profiling and analysis, including liquid chromatography–high resolution mass spectrometry (LC-MS), MS imaging, and lipidomic flux analysis, hold tremendous potential in the diagnostic approach along the drug development process.

In this Special Issue, we seek to bring together research from experts in the field, focusing on novel mass spectrometry-based lipidomics techniques and strategies, their applications in targeted-lipid drug discovery and development, and future perspectives that will enhance our biological understanding of molecular lipid metabolism for precise therapeutic opportunities.

Prof. Dr. Hua Tian
Dr. Fereshteh Zandkarimi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • lipidomics
  • drug discovery
  • LC-MS
  • mass spectrometry imaging
  • lipidomic flux analysis
  • stable isotope tracing

Published Papers

This special issue is now open for submission.
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