Special Issue "Pharmacokinetic Processes of Active Substance in Drug Formulations"
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 1213
2. Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös street 6., H-6720 Szeged, Hungary
Interests: in vitro dissolution/permeability; tissue specific permeability; biomimetic models for drug metabolism; ophthalmic drug formulation; plasma prorein binding; physicochemical profiling; lead optimization; in silico candidate selection
Pharmacokinetic-driven drug formulation is gaining more and more importance in novel drug research and development programs. One of the reasons for this is to be found in the physico-chemical properties of the active ingredient candidates, where mainly poor solubility and/or absorption is a challenge. Another possible reason can be related to various protein and enzyme related PK problems, such as increased plasma protein binding, metabolism and active transport mechanisms. In the face of these problems, there are already many formulation solutions with a new approach available, the knowledge and repertoire of which we would like to enrich with the present special issue. In the Special Issue of Pharmaceuticals ‘Pharmacokinetic Processes of Active Substance in Drug Formulations’, in addition to the new drug formulation and drug delivery systems, we are also expecting the presentation of novel in vitro, in vivo and ex vivo test methods or mechanistic approaches that can be linked to ADME processes, which present dissolution, drug release kinetics, in vitro/ex works related to vivo permeability studies specifically for formulation strategy or test systems for alternative drug delivery routes for drug targeting, smart drug delivery.
Dr. György Tibor Balogh
Manuscript Submission Information
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- dissolution studies
- drug release kinetics
- in vitro/ex vivo permeability studies
- diffusion studies
- exploiting alternative drug delivery routes for drug targeting
- improved bioavailability of poorly water soluble/permeable drugs
- smart drug delivery systems
- complexes facilitation drug release
- metabolism-coupled drug release