Special Issue "Nanotechnology for Drug and Gene Delivery"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1420

Special Issue Editor

Department of Oncology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Interests: nanotechnology; cancer therapy; drug delivery; gene delivery; tumor microenvironment modulation

Special Issue Information

Dear Colleagues,

The advent of nanotechnology has led to the development of novel diagnostic and therapeutic strategies capable of changing how we treat cancer. The properties of nanotechnology can be harnessed to design diagnostic tools that enable the earlier detection and precise monitoring of patient responses to treatment, thus potentially enhancing patient outcomes. Nanotechnology also provides the means to target therapeutic agents both selectively and directly to neoplastic niches, thus enabling the safer delivery of radiotherapy, chemotherapy, and targeted therapies. The benefits of nanomaterials for cancer thus depend on their ability 1) to be easily functionalized an engineered, 2) to act as theranostic (i.e., diagnostic and therapeutic) platforms, 2) to passively accumulate at cancer sites through the EPR effect, 3) to be actively and selectively targeted to tumor cells while avoiding the side effects of traditional therapeutic modalities and 4) to overcome the traditional biological barriers, including the blood–brain barrier or the dense stroma of pancreatic cancer. In this Special Issue, we will explore the various applications of nanotechnology to cancer treatment. We will discuss the latest advances in 1) the application of nanotechnology in cancer detection and diagnosis and 2) nanotherapeutic solutions for cancer treatment including nano-enabled chemotherapy, radiotherapy, immune and targeted therapies, and gene delivery. We will also examine how nanotherapeutic approaches can be used to reprogram the tumor microenvironment to overcome drug resistance. Finally, we will review the current nanotechnology clinical trials.

Dr. Batoul Farran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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  • nanoparticles
  • drug and gene delivery
  • cancer therapy
  • chemotherapy
  • radiotherapy
  • immunotherapy

Published Papers (1 paper)

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33 pages, 2721 KiB  
Nanotechnology-Aided Advancement in Combating the Cancer Metastasis
Pharmaceuticals 2023, 16(6), 899; https://doi.org/10.3390/ph16060899 - 19 Jun 2023
Viewed by 1178
Modern medicine has been working to find a cure for cancer for almost a century, but thus far, they have not been very successful. Although cancer treatment has come a long way, more work has to be carried out to boost specificity and [...] Read more.
Modern medicine has been working to find a cure for cancer for almost a century, but thus far, they have not been very successful. Although cancer treatment has come a long way, more work has to be carried out to boost specificity and reduce systemic toxicity. The diagnostic industry is on the cusp of a technological revolution, and early diagnosis is essential for improving prognostic outlook and patient quality of life. In recent years, nanotechnology’s use has expanded, demonstrating its efficacy in enhancing fields such as cancer treatment, radiation therapy, diagnostics, and imaging. Applications for nanomaterials are diverse, ranging from enhanced radiation adjuvants to more sensitive early detection instruments. Cancer, particularly when it has spread beyond the original site of cancer, is notoriously tough to combat. Many people die from metastatic cancer, which is why it remains a huge issue. Cancer cells go through a sequence of events known as the “metastatic cascade” throughout metastasis, which may be used to build anti-metastatic therapeutic techniques. Conventional treatments and diagnostics for metastasis have their drawbacks and hurdles that must be overcome. In this contribution, we explore in-depth the potential benefits that nanotechnology-aided methods might offer to the detection and treatment of metastatic illness, either alone or in conjunction with currently available conventional procedures. Anti-metastatic drugs, which can prevent or slow the spread of cancer throughout the body, can be more precisely targeted and developed with the help of nanotechnology. Furthermore, we talk about how nanotechnology is being applied to the treatment of patients with cancer metastases. Full article
(This article belongs to the Special Issue Nanotechnology for Drug and Gene Delivery)
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