Recent Advances in Psychopharmacology
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 2062
Special Issue Editors
2. Institute of Psychiatry, Psychology and Neuroscience (IoPPN) Kings College, London, UK
3. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
4. St. John’s National Academy of Health Sciences, Bangalore, India
Interests: psychiatry; (psycho)pharmacology; pharmacogenetics; pharmacogenomics; genetics; pharmacokinetics; pharmacodynamics; pharmacovigilance; drug interactions; phenoconversion
2. South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent BR3 3BX, UK
Interests: psychopharmacology; bipolar disorder; major depressive disorder; novel treatments; cognition
Special Issue Information
Dear Colleagues,
Performing clinical trials in psychiatry is a challenge as it is difficult to include a sufficient number of patients and assess reliable outcome parameters, and due to the fact that drug companies as Astra Zeneca, Pfizer, Glaxo Smith Kline and Eli Lilly have stopped almost all psychopharmaca discoveries [1]. Nevertheless, in a recent overview of all the recent and current phase 2 or phase 3 clinical trials, n=43 were described for schizophrenia medication, n=11 for bipolar disorder, n=56 for major depressive disorder, n=29 for anxiety disorder and trauma related disorders, and n=17 for medication for treatment of substance disorders [2]. One has to bear in mind that, in general, the availability of new psychopharmaca to patients takes nearly nine years, and the likelihood of drug approval in psychiatry is only 6.2%. Thus, novel strategies in psychiatry are urgently needed [3].
We would like to add enhancing medication prescription with pharmacogenetics as another strategy. In general, only one-third of the patients respond to treatment with available medication in psychiatry [4,5]. Today, medication selection in psychiatry relies on a trial-and-error approach based mainly on physicians’ experience [4,5]. Pharmacogenetic testing can help in this process by determining the person-specific genetic factors that may predict clinical response and side effects associated with genetic variants that impact drug-metabolizing enzymes, drug transporters or drug targets [4–8].
In this Special Issue, some exciting examples of newly registered medications in psychiatry will be described, in addition to recent pharmacogenetic advances including the start of a clinical trial implementing pharmacogenetics in people with mood, anxiety, and psychotic disorders.
- Howes OD, Baxter L. The drug treatment deadlock in psychiatry and the route forward. World Psychiatry 2023;22(1): 2-4
- Correll, M. Solmi, S. Cortese, M. Fava, M. Højlund, HC. Kraemer, RS. McIntyre, DS. Pine, LS. Schneider, JM. Kane- The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de-risk trial programmes of novel agents, World Psychiatry 2023;22(1): 48-74
- Yatham LM All levels of the translational spectrum must be targeted to advance psychopharmacology and improve patient outcomes, World Psychiatry 2023;22(1): 75-76
- van Westrhenen& M. Ingelman-Sundberg. Editorial: From Trial and Error to Individualised Pharmacogenomics-Based Pharmacotherapy in Psychiatry. Frontiers in Pharmacology, 2021, doi: 10.3389/fphar.2021.725565
- Dutch Pharmacogenetics Working Group (DPWG) Guideline for the Gene-Drug Interaction between CYP2D6, CYP3A4 and CYP1A2 and Antipsychotics, L. Beunk, M Nijenhuis, B Soree, de Boer-Veger, AM Buunk, H J Guchelaar, EJF Houwink, A Risselada, GAPJM. Rongen, RHN van Schaik, JJ Swen, D Touw, R van Westrhenen, VHM Deneer, J van der Weide Eur J Hum Gen 2023, https://doi.org/10.1038/s41431-023-01347-3
- Dutch Pharmacogenetics Working Group (DPWG) Guideline for the Gene-Drug Interaction between CYP2C19 and CYP2D6 and SSRIs" M. Nijenhuis, J. Brouwer, B. Soree, HJ. Guchelaar, J. Swen, R. van Schaik, J. van der Weide, G. Rongen, AM. Buunk, N. de Boer-Veger, E. Houwink, van Westrhenen, B. Wilffert, V. Deneer, and Hans Mulder. Eur J of Human Gen nov 2021, /doi.org/10.1038/s41431-021-01004-7
- Brown e.a. Pharmacogenomic Testing and Depressive Symptom Remission: A Systematic Review and Meta-Analysis of Prospective, Controlled Clinical Trials, Clin Pharm&Ther 2022; 112(6): 1303-1317
- Swen J, e.a. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet 2023;400(10374): 347-356
Prof. Dr. Roos Van Westrhenen
Prof. Dr. Allan H. Young
Guest Editors
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Keywords
- psychopharmaca
- pharmacogenomics
- pharmacogenetics
- psychedelics
- dementia drugs