Special Issue "Bioactive Compounds and Their Optimized Structural Derivatives of Natural Products"
Deadline for manuscript submissions: 25 April 2024 | Viewed by 1084
Interests: discovery of natural bioactive compounds and their analogue; structural modification of bioactive natural products; biological evaluation and mechanistic investigations of bioactive compounds
Interests: discovery of bioactive natural product and novel natural product; new efficacy and structure-activity relationship of bioactive natural products; mechanism of bioactive natural products and their analogue
As an invaluable source of new drug discoveries, natural products have novel, diverse and complex structures; unique biological activities; and a novel mechanism of action. Through the statistics and collation of the drugs approved by FDA in the past 40 years, it was found that more than 45% of the drugs were derived from natural products and their derivatives, especially antibacterial, antiviral, anti-inflammatory, antioxidant and antitumor drugs. However, natural products generally have relatively low content in nature, a complex structure, relatively difficult synthesis, and certain difficulty in achieving mass production. Lead compounds or drug candidates can be obtained via the structural modification or optimization of natural products. In general, optimizing natural lead compounds into novel drugs or drug candidates not only addresses drug efficacy, but also improves ADMET properties and chemical accessibility associated with natural drugs. This can provide a new way to break through the bottleneck of the development of novel, targeted drugs. This Special Issue aims to summarize the latest research results and progress in the field of natural products. We invite both reviews and original articles that shed light on the discovery of natural bioactive compounds and their analogues, the structural modification of bioactive natural products, biological evaluation and the mechanistic investigations of the bioactive compounds.
Dr. Yanhua Fan
Dr. Shuzhen Mu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- natural products
- bioactive compounds and their derivatives
- isolation and purification
- structural modification or optimization
- biological evaluation
- mechanistic investigations
- an evaluation of ADMET properties