Special Issue "Maximising Drug Delivery for Improved Pharmacokinetics and Pharmacodynamics"
Deadline for manuscript submissions: 31 December 2023 | Viewed by 1751
Interests: drug delivery; drug absorption enhancement; herb–drug interactions; nose-to-brain delivery; ex vivo pharmacokinetic models
Interests: drug delivery; drug absorption enhancement; in vitro pharmacokinetics; herb-drug interactions; nose-to-brain delivery
The pharmaceutical industry is challenged by the poor bioavailability of a large portion of approved and pipeline drugs. Various reasons exist for the poor systemic delivery of these drugs, which include low aqueous solubility, inadequate membrane permeability, high pre-systemic metabolism, susceptibility to absorption barriers such as efflux transporters, and unfavourable physico-chemical properties. Innovative approaches have been employed by scientists to overcome drug delivery challenges in order to maximise bioavailability.This Special Issue of the journal Pharmaceuticals aims at publishing original research and review articles on topics related to the facilitation of drug delivery in order to maximise bioavailability. The following topics form part of the scope of this Special Issue:
- Formulation and dosage form design (e.g., specialised drug delivery devices, permeation enhancers, nanotechnology, inclusion complexes, amorphous solid dispersions, functional excipients, solubilization with surfactants to increase solubility, etc.);
- Alternative routes of drug administration (e.g., pulmonary, intranasal, transdermal, rectal, buccal, sublingual, etc.);
- Targeted drug delivery (e.g., region specific delivery such as colon targeted delivery, nose-to-brain delivery, etc.);
- Chemical strategies (e.g., structural modification, prodrugs, salts, conjugation with proteins, etc.);
- Physical strategies (e.g., magnetic retention, expandable systems, microneedles, iontophoresis, etc.).
Prof. Dr. Sias Hamman
Dr. Dewald Steyn
Dr. Marius Brits
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drug delivery
- absorption enhancement
- alternative route of drug administration