Special Issue "New Psychoactive Natural Products"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 20 February 2024 | Viewed by 119

Special Issue Editors

Coimbra Institute for Clinical and Biomedical Research (iCBR)/Center for Innovative Biomedicine and Biotechnology (CIBB)/Clinical Academic Center of Coimbra (CACC), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: ethnomedicine; phytochemistry; natural products; bioactive compounds; plant-based health solutions
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Coimbra Institute for Biomedical Imaging and Translational Research, Instituto de Ciências Nucleares Aplicadas à Saúde, University of Coimbra, 3004-531 Coimbra, Portugal
Interests: cognitive and Clinical neuroscience; perception, emotion, decision-making, multimodal approaches
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1. CNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
2. CIBB—Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal
3. IIIUC—Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal
Interests: biology and ecology of fungi; functional attributes of fungi; forest and human dimensions
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Special Issue Information

Dear Colleagues,

According to the WHO, traditional medicine is “the sum total of the knowledge, skill, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness”. There are many different systems of traditional medicine, and their philosophy and practices have distinct influences. A common principle is a holistic approach to life, with a balance between the mind, body, and environment, and an emphasis on processes that restore and maintain health, rather than on disease.

Natural products are, in general, rich in a variety of compounds; many of them are secondary metabolites, aromatic and non-aromatic substances. About 200 years ago, the first pharmacologically active pure compound, the isoquinoleic alkaloid morphine, was extracted from the seed pods of the opium poppy Papaver somniferum L. Similarly, the psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine), a secondary metabolite produced by several groups of fungi and widely associated with rituals in ancient times, is extremely helpful for furthering our understanding of how brain activity relates to altered states of consciousness. Many compounds have been isolated from natural sources, demonstrating that drugs from plants and fungi could be purified and administered in precise dosages.

The potential therapeutic application of natural matrices is extremely dependent on the chemical class(es) of their compounds. The research of psychoactive natural products, both alone and in mixtures of different species, has expanded in recent years. Understanding the mechanisms underlying these effects in brain function could potentially provide insights regarding the application of novel therapeutic approaches to various brain diseases and disorders.

Authors are welcome to submit their research addressing natural products with psychoactive properties. Some suggested topics are as follows:

- Identifying new clinical applications of psychoactive natural products
- Probing the neural mechanisms of action underlying psychological manifestations, at functional and molecular levels
- Drug delivery strategies
- Potentially addictive properties of psychoactive drugs
- Applications in pain research.

Prof. Dr. Célia Cabral
Prof. Dr. Miguel Castelo-Branco
Prof. Dr. Anabela Marisa Azul
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neuropharmacology
  • brain imaging
  • etnopharmacology
  • natural products
  • drug delivery

Published Papers

This special issue is now open for submission.
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