Advances in Neuropharmacology of Drug Abuse

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 3914

Special Issue Editor


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Guest Editor
1. Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hertfordshire AL10 9EU, UK
2. Department of Neuroscience, Imaging and Clinical Sciences, “G. D’Annunzio” University, 66100 Chieti, Italy
Interests: misuse and abuse of psychoactive substances and their clinical pharmacological characteristics; pharmacovigilance approach to assess a vast range of prescribed medications’ levels of liability misuse; psychopharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the substance abuse scenario has changed considerably. Indeed, although the use of substances commonly considered 'traditional', such as THC, cocaine, and opioids, remains high, the use of medications to achieve psychoactive effects (known as 'pharming') and the advent of new psychoactive substances (NPS) have contributed to a change in the prevalence and consumption of substances. The effects of such substances can range from acute toxicity to death, depending on dosage, route of administration, and concomitant use of other psychoactive drugs. Clearly, the strictly pharmacological and toxicological aspects are not always clear, sometimes because the substance being taken, its properties, and possible pharmacokinetic and pharmacodynamic interactions are not always known.

This Special Issue aims to provide an up-to-date overview of the pharmacology, clinical information, and toxicology of psychotropic drugs, both licit and illicit, and the effects associated with their use. Finally, it includes detection strategies that can be adopted in the initial clinical assessment of patients.

The journal Pharmaceuticals invites reviews, meta-analysis, brief reports, and original articles. Topics may include:

  • psychopharmacology, toxicology, and pharmacology of psychotropics;
  • addiction and drug misuse;
  • and finally, new psychoactive substances.

The collection of manuscripts will be published as a Special Issue of the journal.

Dr. Stefania Chiappini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuropharmacology
  • drug abuse
  • addiction
  • substance abuse

Published Papers (1 paper)

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Research

13 pages, 1937 KiB  
Article
Is There a Risk for Semaglutide Misuse? Focus on the Food and Drug Administration’s FDA Adverse Events Reporting System (FAERS) Pharmacovigilance Dataset
by Stefania Chiappini, Rachel Vickers-Smith, Daniel Harris, G. Duccio Papanti Pelletier, John Martin Corkery, Amira Guirguis, Giovanni Martinotti, Stefano L. Sensi and Fabrizio Schifano
Pharmaceuticals 2023, 16(7), 994; https://doi.org/10.3390/ph16070994 - 11 Jul 2023
Cited by 6 | Viewed by 3458
Abstract
Recent media reports commented about a possible issue of the misuse of antidiabetics related to molecules promoted as a weight-loss treatment in non-obese people. We evaluated here available pharmacovigilance misuse/abuse signals related to semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, in comparison to [...] Read more.
Recent media reports commented about a possible issue of the misuse of antidiabetics related to molecules promoted as a weight-loss treatment in non-obese people. We evaluated here available pharmacovigilance misuse/abuse signals related to semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, in comparison to other GLP-1 receptor agonists (albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide, and tirzepatide) and the phenterminetopiramate combination. To acheieve that aim, we analyzed the Food and Drug Administration’s FDA Adverse Events Reporting System (FAERS) dataset, performing a descriptive analysis of adverse event reports (AERs) and calculating related pharmacovigilance measures, including the reporting odds ratio (ROR) and the proportional reporting ratio (PRR). During January 2018–December 2022, a total of 31,542 AERs involving the selected molecules were submitted to FAERS; most involved dulaglutide (n = 11,858; 37.6%) and semaglutide (n = 8249; 26.1%). In comparing semaglutide vs. the remaining molecules, the respective PRR values of the AERs ‘drug abuse’, ‘drug withdrawal syndrome’, ‘prescription drug used without a prescription’, and ‘intentional product use issue’ were 4.05, 4.05, 3.60, and 1.80 (all < 0.01). The same comparisons of semaglutide vs. the phentermine–topiramate combination were not associated with any significant differences. To the best of our knowledge, this is the first study documenting the misuse/abuse potential of semaglutide in comparison with other GLP1 analogues and the phentermine–topiramate combination. The current findings will need to be confirmed by further empirical investigations to fully understand the safety profile of those molecules. Full article
(This article belongs to the Special Issue Advances in Neuropharmacology of Drug Abuse)
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