Special Issue "Methyl-Containing Pharmaceuticals"
Deadline for manuscript submissions: 29 December 2023 | Viewed by 4475
Interests: organic synthesis; catalysis; small molecules
Discovering and developing new pharmaceuticals is the main goal of medicinal chemistry research. For this Special Issue, we will consider manuscripts focused on any type of target involved in pharmaceutical methyl-containing profiles, from peptides to anti-fungal/anti-tumoral targets, considering a broad spectrum of applications. For example, there are pharmaceuticals targeting GPCRs (multiple G protein-coupled receptors), that are present on the cell surface of every cell type to regulate key physiological events. They mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so they have potential as therapeutic targets for a broad spectrum of diseases. Even the smallest modification of a molecule can lead to the discovery of an important therapeutic effect. The methyl effect is well acknowledged in medicinal chemistry; the insertion of the smallest alkyl group could have important implications in modulating the biological activity, selectivity, solubility, metabolism and pharmacokinetic/pharmacodynamic properties of the bioactive molecules already highlighted. The purpose of this Special Issue is to combine synthetic strategies to methylate potential drug profiles with the identification of pharmaceuticals through significant lead optimization processes to create new biologically active compounds because, as highlighted, a minimal structural substitution could result in significant and unexpected behavioral modifications.
Dr. Anna Fantinati
Dr. Davide Illuminati
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drugs discovery