Special Issue "20th Anniversary of Pharmaceuticals—Therapeutic Mechanisms of Nature Products against Insulin Resistance 2024"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 144

Special Issue Editors

Biocommunication in Cardio-Metabolism (BC2M), Faculty of Pharmacy, University of Montpellier, Montpellier, France
Interests: type 2 diabetes; obesity; pancreatic β-cells; insulin resistance; nitric oxide; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Qualisud, Faculty of Sciences, University of Montpellier, CIRAD, SupAgro, Montpellier, France
Interests: natural compounds; asteracea; caffeic acid derivatives; metabolic syndrome; type 2 diabetes; insulin resistance; antioxidant; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Insulin resistance corresponds to a reduced responsiveness of insulin-sensitive tissues to physiological levels of insulin. This disorder is present in several diseases, such as metabolic syndrome, type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) and cardiovascular diseases. Insulin resistance is often recognized as the primary defect leading to type 2 diabetes. During early phases of diabetes, compensatory insulin hypersecretion allows insulin resistance to be counteracted and normoglycemia to be maintained. Thereafter, progressive pancreatic β-cell failure is responsible for a decrease in insulin secretion, leading to chronic hyperglycemia. The main drivers of insulin resistance are related to obesity, decreased exercise practices and the overconsumption of high-fat and high-carbohydrate food. To improve metabolic disorders, such as type 2 diabetes, pharmacological strategies include insulin sensitizers (biguanides, thiazolidinediones), insulin secretagogues (e.g., sulphonylureas), alphaglucosidase inhibitors and sodium–glucose co-transporter 2 inhibitors. Natural products are also a source of active compounds that could be useful tools to improve metabolic disorders in combination with pharmacological drugs. They can originate from plants, animals, fungus, algae, microorganisms, food ingredients and traditional medicine, and can act directly on insulin resistance to improve glucose homeostasis. They can target insulin-sensitive tissues, such as skeletal muscle, adipose tissues, liver or the cardiovascular system. Their mechanisms of action can identify molecular targets in order to use them in combination with other pharmacological drugs.We thus invite researchers to provide studies investigating the therapeutic mechanisms of natural products on target tissues that contribute to insulin resistance at cellular and molecular levels.

Prof. Dr. Anne-Dominique Lajoix
Dr. Didier Tousch
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • insulin resistance
  • signaling pathways
  • liver
  • skeletal muscle
  • adipose tissues
  • traditional medicine
  • plants
  • fungus
  • algae
  • food ingredients

Published Papers

This special issue is now open for submission.
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