Special Issue "Polymorphs, Salts, Cocrystals and Cationic Lipid Nanoparticle Complexes in Drug Delivery"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 10 February 2024 | Viewed by 63

Special Issue Editor

Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47906, USA
Interests: solid state chemistry; pair distribution function; synchrotron X-ray diffraction; solid nanoparticles; drug quality; polymorphs; salts; cocrystals; amorphous forms

Special Issue Information

Dear Colleagues,

This Special Issue will explore drug delivery strategies based on solid state chemistry structures including polymorphs, salts and cocrystals.  Drug delivery approaches from newer solid-state systems, including solid lipid nanoparticles and solid drug-polymer systems, were also discussed. The overall goal is to understand how to use these structures to improve drug delivery and avoid instances such as the Ritonavir disaster. The theme linking these areas together is the common search for solid dosage forms or lyophilized solid materials that can be easily reconstituted for the delivery of drugs to the patient.  Polymorphs have been known to play a major role in drug delivery due to their different solubility for many years. Different types of hydrogen bonding often hold polymorphs of drugs together. Salts can have an even greater influence on drug delivery, as shown in the landmark paper by Eino Nelson in the 1950s.  Salts are, of course, held together by ionic forces and in some cases, hydrogen bonding. Although cocrystals are not salts, in many cases, they are also held together by ionic forces or hydrogen bonding. Cationic solid drug–lipid nanoparticles and solid ionic drug–polymer complexes are assuming much more importance since RNA vaccines were introduced. Their structures are also held together by salt/ionic complexation. In these systems, nucleic acid salts are bound to cationic lipids and these ionic interactions play an important role in drug delivery systems. This Special Issue will explore the influence of all of these structures and forces on drug delivery. The goal is to understand how to use these various systems to optimize drug delivery and improve patient therapy.

Prof. Dr. Stephen Robert Byrn
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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