Special Issue "Polymorphs, Salts, Cocrystals and Cationic Lipid Nanoparticle Complexes in Drug Delivery"
Deadline for manuscript submissions: 10 February 2024 | Viewed by 63
Interests: solid state chemistry; pair distribution function; synchrotron X-ray diffraction; solid nanoparticles; drug quality; polymorphs; salts; cocrystals; amorphous forms
This Special Issue will explore drug delivery strategies based on solid state chemistry structures including polymorphs, salts and cocrystals. Drug delivery approaches from newer solid-state systems, including solid lipid nanoparticles and solid drug-polymer systems, were also discussed. The overall goal is to understand how to use these structures to improve drug delivery and avoid instances such as the Ritonavir disaster. The theme linking these areas together is the common search for solid dosage forms or lyophilized solid materials that can be easily reconstituted for the delivery of drugs to the patient. Polymorphs have been known to play a major role in drug delivery due to their different solubility for many years. Different types of hydrogen bonding often hold polymorphs of drugs together. Salts can have an even greater influence on drug delivery, as shown in the landmark paper by Eino Nelson in the 1950s. Salts are, of course, held together by ionic forces and in some cases, hydrogen bonding. Although cocrystals are not salts, in many cases, they are also held together by ionic forces or hydrogen bonding. Cationic solid drug–lipid nanoparticles and solid ionic drug–polymer complexes are assuming much more importance since RNA vaccines were introduced. Their structures are also held together by salt/ionic complexation. In these systems, nucleic acid salts are bound to cationic lipids and these ionic interactions play an important role in drug delivery systems. This Special Issue will explore the influence of all of these structures and forces on drug delivery. The goal is to understand how to use these various systems to optimize drug delivery and improve patient therapy.
Prof. Dr. Stephen Robert Byrn
Manuscript Submission Information
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