Special Issue "Drug Candidates for the Prevention and Treatment of Cardiovascular Diseases in Patients with Diabetes Mellitus"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 July 2023 | Viewed by 1031

Special Issue Editor

Medical School, University of Cyprus, 2029 Nicosia, Cyprus
Interests: cardiovascular disease prevention; atherosclerotic plaque vulnerability; heart failure
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes mellitus (DM) has already evolved into an epidemic in developing countries, and especially in the western world. It is well-known that diabetic patients have a 2- to 4-fold higher risk for cardiovascular diseases (CVDs). Moreover, the presence of DM remarkably increases the incidence of cardiovascular events in patients with established CVDs despite the administration of optimum pharmaceutical therapy. The re-vascularization procedures in coronary and peripheral arteries are characterized by a higher incidence of complications in patients with DM than their non-diabetic counterparts. Therefore, there is still an increasing need to develop and apply more effective medications for primary and secondary prevention of CVDs (ischemic and non-ischemic) in the DM population. 

The aim of the present Special Issue is to attract more than 10 high-quality papers that focus on drugs with potentiality to contribute to CVD prevention and treatment in diabetic patients. Those drug candidates may be substances that target several aspects of pathophysiological mechanisms of CVDs or may comprise therapeutic regimes of other, non-cardiovascular diseases, with potential expansion of their indications to CVDs. Among all, established and novel, especially gene-oriented, lipid-lowering agents remain the cornerstone of prevention and treatment of ischemic CVDs. Medicinal chemistry has introduced technological and conceptual innovations with wide potential application in CVDs. In this Special Issue, we also expect manuscripts providing evidence or summarizing the expanding cardiovascular benefits of current anti-diabetic medications, such as sodium–glucose co-transporter 2 inhibitors, or of candidate drugs. The anti-inflammatory agents and immunomodulators used in auto-immune diseases have opened a new era in the pharmaceutical treatment of patients with CVDs. In addition to this, other drugs targeting the main pathophysiological mechanisms of myocardial or vascular remodeling, such as the inhibition of myocardial fibrosis or vascular wall inflammatory infiltration, respectively, are also quite promising. Finally, herbal medicine remains a very promising source of drug candidates and requires further investigation. These taken together, there is an increasing number of drugs that could serve effectively in the primary and secondary prevention of CVDs in DM in order to improve the survival and the quality of life of diabetic patients.

Dr. Nikolaos Kadoglou
Guest Editor

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  • diabetes mellitus
  • lipid lowering
  • anti-diabetic drugs
  • hypercholesterolemia
  • hypertriglyceridemia
  • PCSK9
  • SGLT-2
  • immunomodulators
  • gene therapy
  • anti-inflammatory drugs
  • regenerative medicine
  • herbal medicine

Published Papers (1 paper)

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Effects of Statin Dose, Class, and Use Intensity on All-Cause Mortality in Patients with Type 2 Diabetes Mellitus
Pharmaceuticals 2023, 16(4), 507; https://doi.org/10.3390/ph16040507 - 29 Mar 2023
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Purpose: to examine the impact of statins on reducing all-cause mortality among individuals diagnosed with type 2 diabetes. This investigation explored the potential correlations between dosage, drug classification, and usage intensity with the observed outcomes. Methods: The research sample consisted of individuals aged [...] Read more.
Purpose: to examine the impact of statins on reducing all-cause mortality among individuals diagnosed with type 2 diabetes. This investigation explored the potential correlations between dosage, drug classification, and usage intensity with the observed outcomes. Methods: The research sample consisted of individuals aged 40 years or older diagnosed with type 2 diabetes. Statin usage was determined as a frequent usage over a minimum of one month subsequent to type 2 diabetes diagnosis, where the average statin dose was ≥28 cumulative defined daily doses per year (cDDD-year). The analysis employed an inverse probability of treatment-weighted Cox hazard model, utilizing statin usage status as a time-varying variable, to evaluate the impact of statin use on all-cause mortality. Results: The incidence of mortality was comparatively lower among the cohort of statin users (n = 50,804 (12.03%)), in contrast to nonusers (n = 118,765 (27.79%)). After adjustments, the hazard ratio (aHR; 95% confidence interval (CI)) for all-cause mortality was estimated to be 0.32 (0.31–0.33). Compared with nonusers, pitavastatin, rosuvastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, and lovastatin users demonstrated significant reductions in all-cause mortality (aHRs (95% CIs) = 0.06 (0.04–0.09), 0.28 (0.27–0.29), 0.29 (0.28–0.31), 0.31 (0.30–0.32), 0.31 (0.30–0.32), 0.36 (0.35–0.38), and 0.48 (0.47–0.50), respectively). In Q1, Q2, Q3, and Q4 of cDDD-year, our multivariate analysis demonstrated significant reductions in all-cause mortality (aHRs (95% CIs) = 0.51 (0.5–0.52), 0.36 (0.35–0.37), 0.24 (0.23–0.25), and 0.13 (0.13–0.14), respectively; p for trend <0.0001). Because it had the lowest aHR (0.32), 0.86 DDD of statin was considered optimal. Conclusions: In patients diagnosed with type 2 diabetes, consistent utilization of statins (≥28 cumulative defined daily doses per year) was shown to have a beneficial effect on all-cause mortality. Moreover, the risk of all-cause mortality decreased as the cumulative defined daily dose per year of statin increased. Full article
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