Special Issue "Nanoparticulate Delivery Systems for Antiviral Drugs"
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2707
Interests: nanoparticles; drug delivery systems; hydrogels; cell-membrane coating
The COVID-19 pandemic has brought the great demand for effective antiviral therapy into focus. Antiviral drugs are extensively used to combat viral infections, mainly through targeting the common stages of the viral life cycle, including entry (inhibitors of host proteins or viral surface submission), biosynthesis (inhibitors of nucleic acid polymerases or integrases), assembly (inhibitors of proteases), and release (inhibitors of neuraminidases). However, the delivery of antiviral drugs, especially small molecules and antibodies, is largely confronted with some challenges, notably in stability, off-target accumulation and intracellular delivery requirements. Remarkably, nanoparticulate delivery systems have been developed to overcome these limitations thanks to their small size and unique physicochemical and biological properties. Various nanostructures, including extracellular vesicles, liposomes, dendrimers, polymers, silicon or carbon materials, nanogels, and magnetic nanoparticles, have been applied as carriers in antiviral drug delivery. Compared with traditional treatments, these nanoscale carriers largely strengthen the long-term circulation, local penetration, microenvironment targeting, and controlled release of antiviral drugs. Furthermore, the size, shape, charge, and surface modification of nanoparticles determine the fate of antiviral drugs in body. This Special Issue of Pharmaceuticals aims to assemble the recent developments in the field of nanoparticulate delivery systems for antiviral drugs. Contributions can be submitted in the form of original or review articles concerning the latest advances. The considered papers should include, but are not limited to, the following aspects: Development of methods for the preparation of nanoparticulate delivery systems for antiviral drugs. Evaluation of the biochemical or biophysical properties of antiviral drugs. Modification of nanoparticulate material for better performance. Pharmacokinetics and pharmacodynamics of nanoparticulates as antiviral drug delivery systems. Related mechanisms of nanoparticulate-based antiviral drug delivery systems. Diagnostic, therapeutic or clinical applications of nanoparticulate-based antiviral drug delivery systems for different viral infections.
Dr. Yan Pang
Dr. Lu Wang
Manuscript Submission Information
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- biomedical applications
- antiviral drug
- targeted delivery
- controlled release
- virus infection