Special Issue "Unraveling the Multifaceted Role of Polyphenols in Health Issues"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 70

Special Issue Editors

LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal
Interests: polyphenols; anthocyanins; natural pigments; bioavailability; bioactivity
Special Issues, Collections and Topics in MDPI journals
REQUIMTE/LAQV, Faculdade de Ciências da Universidade do Porto, Rua do Campo 6 Alegre, 689, 4169-007 Porto, Portugal
Interests: agro-food residues and wastes; anthocyanins; functional food; polysaccharides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polyphenols have garnered increasing attention for their potential health-promoting properties not only among the scientific community but also among the general population. Polyphenols encompass a wide array of chemical compounds, including flavonoids, phenolic acids, lignans, and stilbenes, each with unique structures and bioactive properties. Their presence in nature extends to fruits, vegetables, whole grains, nuts, seeds, tea, coffee, and even some spices, contributing to the vibrant colors, flavors, and protective mechanisms of these foods.

Across the globe, dietary patterns rich in polyphenol-containing foods have been integral to traditional cuisines. These dietary habits have not only shaped cultural identities but have also been associated with lower incidences of chronic diseases.

The scientific community has amassed substantial evidence regarding the role of polyphenols in preventing and managing major health issues. Numerous epidemiological studies have established associations between higher polyphenol intake and reduced risks of diabetes, cancer, cardiovascular diseases, neurodegenerative disorders, and more. The biological mechanisms underlying these protective effects include antioxidant properties, anti-inflammatory activities, modulation of cellular signaling pathways, and interactions with gut microbiota. Besides that, recent studies have shown that the interaction of polyphenols with the food matrix (such as polysaccharides and proteins) may play a critical role in polyphenol stability and consequent bioactivity.

With this Special Issue, we want to bring together leading experts to review and present the latest research findings and clinical trials that elucidate the connections between polyphenols and health outcomes. It aims to provide a comprehensive overview of the current state of knowledge regarding the therapeutic potential of polyphenols in food, for the management and prevention of diseases, ultimately contributing to a better understanding of their role in promoting global health.

As guest editors, we kindly invite you to submit your latest research or an updated review on this issue.

Dr. Hélder Oliveira
Dr. Ana Fernandes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • polyphenols
  • bioactivity
  • bioavailability
  • functional foods
  • polysaccharides

Published Papers

This special issue is now open for submission.
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