Special Issue "Unraveling the Multifaceted Role of Polyphenols in Health Issues"

Dear Colleagues,

Polyphenols have garnered increasing attention for their potential health-promoting properties not only among the scientific community but also among the general population. Polyphenols encompass a wide array of chemical compounds, including flavonoids, phenolic acids, lignans, and stilbenes, each with unique structures and bioactive properties. Their presence in nature extends to fruits, vegetables, whole grains, nuts, seeds, tea, coffee, and even some spices, contributing to the vibrant colors, flavors, and protective mechanisms of these foods.

Across the globe, dietary patterns rich in polyphenol-containing foods have been integral to traditional cuisines. These dietary habits have not only shaped cultural identities but have also been associated with lower incidences of chronic diseases.

The scientific community has amassed substantial evidence regarding the role of polyphenols in preventing and managing major health issues. Numerous epidemiological studies have established associations between higher polyphenol intake and reduced risks of diabetes, cancer, cardiovascular diseases, neurodegenerative disorders, and more. The biological mechanisms underlying these protective effects include antioxidant properties, anti-inflammatory activities, modulation of cellular signaling pathways, and interactions with gut microbiota. Besides that, recent studies have shown that the interaction of polyphenols with the food matrix (such as polysaccharides and proteins) may play a critical role in polyphenol stability and consequent bioactivity.

With this Special Issue, we want to bring together leading experts to review and present the latest research findings and clinical trials that elucidate the connections between polyphenols and health outcomes. It aims to provide a comprehensive overview of the current state of knowledge regarding the therapeutic potential of polyphenols in food, for the management and prevention of diseases, ultimately contributing to a better understanding of their role in promoting global health.

As guest editors, we kindly invite you to submit your latest research or an updated review on this issue.

Dr. Hélder Oliveira
Dr. Ana Fernandes
Guest Editors

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• polyphenols
• bioactivity
• bioavailability
• functional foods
• polysaccharides