Special Issue "Hybrid Drugs: Design and Applications 2024"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 15 January 2024 | Viewed by 87

Special Issue Editors

School of Chemistry, University of KwaZulu-Natal, Durban, South Africa
Interests: synthetic methodology; computational chemistry and molecular modelling; pharmacophore design; medicinal Chemistry; ligand–protein interactions; peptide folding; docking
Special Issues, Collections and Topics in MDPI journals
Department of Chemistry, Guru Nanak Dev University, Amritsar, India
Interests: molecular hybridization; anti-plasmodials; anti-mycobacterials; bio-organometallic chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Shalini
E-Mail Website
Guest Editor
Department of Chemistry, The University of Iowa, Iowa City, IA, USA
Interests: natural product chemistry; neglected tropical diseases

Special Issue Information

Dear Colleagues,

The general belief that agents modulating multiple biological targets could outperform single-target drugs has paved the way for the introduction of molecular hybridization as an efficient technique in drug discovery and development. The aim of this approach is to combine two (or more) pharmacophoric/bioactive subunits into a new, single chemical entity known as a hybrid molecule. When compared to its parent drugs, the new hybrid molecule may have higher affinity and efficacy, a modified selectivity profile with enhanced pharmacokinetic and pharmacodynamic restrictions, dual or multiple modes of action, minimized undesirable side effects, decreased drug–drug interactions, the reduced emergence or spread of drug resistance in pathogens, and a lower cost.

Trioxaquines, for example, are antimalarial hybrid drugs that are effective against multiresistant strains of Plasmodium falciparum. The antimalarial activity of its two separate precursors is limited, demonstrating the synergistic effect of their covalent binding. Palumed has prepared over 100 trioxaquines, and the trioxaquine PA1103-SAR116242 was selected as a candidate for preclinical development in 2007 in collaboration with Sanofi-Aventis. Estramustine is an anticancer drug that is a combination of a steroid and nitrogen mustard. This is an effective treatment for metastatic and/or progressive prostate cancer. Panobinostat (LBH-589) is a marketed drug used to treat multiple myeloma because it inhibits multiple histone deacetylase enzymes, causing apoptosis in malignant cells.

The major challenges present in developing new molecular hybrids that target complex diseases include selecting the correct target combination and achieving balanced activity while retaining drug-like properties. Nonetheless, hybridization is gaining popularity in academia and industry as a valuable tool for developing novel drugs for diseases such as cancer, malaria, tuberculosis, Alzheimer's, and others.

Dr. Parvesh Singh
Dr. Vipan Kumar
Dr. Shalini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • molecular hybrids
  • anticancer
  • neglected tropical diseases
  • anti-Alzheimer
  • anti-HIV

Published Papers

This special issue is now open for submission.
Back to TopTop