Special Issue "Recent Advances in Congenital Anomalies of the Kidneys and Urinary Tract (CAKUT)"
A special issue of Pediatric Reports (ISSN 2036-7503).
Deadline for manuscript submissions: 30 June 2025 | Viewed by 6376
Interests: nephrology; genetics; urinary tract infection; glomerulonephritis
Interests: pediatric nephrology; congenital malformations of urinary tract; prenatal diagnosis; enuresis; chronic kidney disease
Interests: clinical nephrology; renal disease; nephrology urinary; infections; nephrotic syndrome; pediatric nephrology
Special Issues, Collections and Topics in MDPI journals
Topical Collection in Biomedicines: Progression of Chronic Kidney Disease
Special Issue in Biomedicines: Renal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches 2.0
Special Issue in Biomedicines: Recent Advances in Kidney Disease in Children
Congenital anomalies of the kidneys and urinary tract (CAKUT) are common malformations and may produce variable kidney damage, which, in some cases, leads to end-stage renal disease (ESRD). CAKUT constitute a frequent cause of birth defects (approximately three to six per 1000 live births). CAKUT may occur either as an isolated condition or as part of a syndromic disorder. CAKUT account for 20%–30% of congenital malformations and produce about 40% of cases of ESRD within the first three decades of life. Monogenic mutations are responsible of CAKUT in 10–15 % of cases; new genetic studies, including whole-exome sequencing, provide an etiologic diagnosis for many patients. Hereditary cystic kidney diseases comprise a complex group of genetic disorders including autosomal recessive polycystic kidney disease, neph-ronophthisis, Bardet–Biedl syndrome, and hepatocyte nuclear factor-1beta nephropathy; progress in the molecular understanding of hereditary cystic kidney diseases has been made in recent years. Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of renal failure in adults, but it is well known that the disease course begins in childhood; however, we ignore how to manage and approach children diagnosed with or at risk of ADPKD. Vesicoureteral reflux (VUR) is defined as the retrograde movement of urine from the bladder into the ureter(s); several studies published in the past ten years have questioned the traditional diagnostic and therapeutic recommendations of VUR. Children may present with a solitary functioning kidney (SFK) as a consequence of a congenital non-functioning kidney, or after nephrectomy, SFK may lead to renal injury that may end in end-stage renal disease (ESRD). According to the hyperfiltration hypothesis, an SFK may lead to glomerular damage with hypertension, albuminuria, and progression towards end-stage renal disease, but other factors may play a role.
Prof. Dr. Velibor Tasic
Prof. Dr. Marcin Tkaczyk
Dr. Silvio Maringhini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pediatric Reports is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- genetics of CAKUT
- prenatal diagnosis and fetal surgery in CAKUT
- single kidney—long-term consequences for children and adolescents
- ADPKD in childhood and adolescence
- vesicoureteral reflux (VUR) and kidney disease
- progression of renal disease in CAKUT